Hovi M, Sukupolvi S, Edwards M F, Rhen M
National Public Health Institute, Helsinki, Finland.
Microb Pathog. 1988 May;4(5):385-91. doi: 10.1016/0882-4010(88)90066-6.
Plasmid-associated virulence of Salmonella enteritidis was studied using plasmid-cured and plasmid-reintroduced strains. The plasmidless strain was unable to grow in the liver of mice after intravenous inoculation. Reintroduction of the plasmid pEX106 from the original S. enteritidis fully restored its capacity to grow in the mice. The plasmid pEX102 of Salmonella typhimurium introduced into the plasmid-cured S. enteritidis had a similar effect. The smooth lipopolysaccharide character of the S. enteritidis strains was not affected by the presence or absence of the plasmid, and the same was true of their high resistance to complement in guinea-pig serum as such or with added antibody.
利用质粒消除和质粒重新导入菌株研究了肠炎沙门氏菌的质粒相关毒力。无质粒菌株经静脉接种后无法在小鼠肝脏中生长。从原始肠炎沙门氏菌重新导入质粒pEX106可完全恢复其在小鼠体内生长的能力。将鼠伤寒沙门氏菌的质粒pEX102导入质粒消除的肠炎沙门氏菌也有类似效果。肠炎沙门氏菌菌株的光滑脂多糖特性不受质粒存在与否的影响，其对豚鼠血清中补体本身或添加抗体后的高抗性也是如此。
