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在低强度干预前后,耶鲁-布朗强迫症量表(Y-BOCS)上自我评估和临床医生评估的症状严重程度的一致性和差异。

Congruence and discrepancy between self-rated and clinician-rated symptom severity on the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) before and after a low-intensity intervention.

机构信息

Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany; School of Psychological Sciences, Tel Aviv University, Tel Aviv 69978, Israel.

School of Psychological Sciences, Tel Aviv University, Tel Aviv 69978, Israel.

出版信息

Psychiatry Res. 2019 Mar;273:595-602. doi: 10.1016/j.psychres.2019.01.092. Epub 2019 Jan 29.

Abstract

The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) is the most common measure of Obsessive-Compulsive symptom severity. The Y-BOCS interview is considered gold standard, but its self-rating format is increasingly used in clinical trials. Few studies investigated congruency and potential changes over treatment. This question is highly relevant, as a systematic bias might obscure results of clinical trials. We examined the relationship of self- and clinician-rated Y-BOCS scores in participants with obsessive-compulsive disorder in pre (N = 128), post, (4 weeks, n = 104) and follow-up (6 months, n = 98) assessments of a randomized-controlled clinical trial. We administered Y-BOCS interview via telephone paralleling online administration of the self-report form. Analyses showed medium-to-strong correlations of Y-BOCS interview and self-rating scores at pre-assessment. Patients rated symptoms lower than clinicians. Larger discrepancies were associated with hoarding and age. Congruency was inferior for obsessions relative to compulsions, largely owing to the "resistance against obsessions" item. Agreement strongly increased at post and follow-up. Though overall congruency between the two Y-BOCS forms was satisfactory, results suggest a "correction over time" effect. Such bias may distort the precise interpretation of treatment effects. Therefore, we made several suggestions to improve the reliability of change scores assessed with the Y-BOCS self-rating.

摘要

耶鲁-布朗强迫症量表(Y-BOCS)是衡量强迫症症状严重程度最常用的工具。Y-BOCS 访谈被认为是金标准,但它的自评格式在临床试验中越来越多地被使用。很少有研究调查一致性和治疗过程中的潜在变化。这个问题非常重要,因为系统偏差可能会掩盖临床试验的结果。我们在一项随机对照临床试验的预评估(N=128)、后评估(4 周,n=104)和随访评估(6 个月,n=98)中,检查了强迫症患者的自我和临床医生评定的 Y-BOCS 评分之间的关系。我们通过电话进行 Y-BOCS 访谈,同时在线进行自我报告表格的管理。分析显示,在预评估时,Y-BOCS 访谈和自评分数之间存在中等至强相关。患者对症状的自评低于临床医生的评估。更大的差异与囤积和年龄有关。与强迫相比,强迫观念的一致性较差,这主要归因于“对强迫观念的抵抗”这一项目。在随后的评估中,一致性大大提高。尽管两种 Y-BOCS 形式的总体一致性令人满意,但结果表明存在“随时间修正”的效果。这种偏差可能会扭曲对治疗效果的精确解释。因此,我们提出了一些建议,以提高使用 Y-BOCS 自评评估的变化分数的可靠性。

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