Li L, Ren Q Y, Mai Y P
Department of Otorhinolaryngology Head and Neck Surgery, Guangdong General Hospital Zhuhai Hospital，Zhuhai Golden Bay Center Hospital, Zhuhai, 519040, China.
Department of Otorhinolaryngology Head and Neck Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Nov;32(22):1714-1718. doi: 10.13201/j.issn.1001-1781.2018.22.008.
Patients with laryngopharyngeal reflux frequently experience voice-related symptoms. This was a prospective study that designed to investigate the effectiveness of combined voice and medical therapy in comparison with medical therapy alone in the improvement of voice-related symptoms and parameters in patients with laryngopharyngeal reflux. In this prospective study, total of 71 patients diagnosed with laryngopharyngeal reflux with voice symptoms were randomly divided into 2 groups (A and B). Thirty-five patients in group A were treated with medication alone, and 36 patients in group B were treated with medication plus voice therapy. The following data were recorded before treatment and at the end of treatment and 1, 2 months posttreatment: reflux symptom index(RSI), reflux finding score (RFS), voice handicap index(VHI), and change in grade, roughness, breathiness, asthenia, and strain scale (GRBAS) were analysised. The Electronic laryngoscopywere performed to assess efficacy. The numbers of patients showing clinically significant reductions in these parameters were compared between groups. Significantly more patients in the B group showed a clinically significant change in RSI, VHI, and GRBAS score at the end time, 1-, and 2-month follow-up evaluations. No clinically significant change in RFS was achieved in either group at the end time or 1 month, but a significantly greater change was achieved in the study group at 2 months. Voice therapy may help to restore reversible mucosal change secondary to acidic reflux, inducing rapid resolution of symptoms and shortening of the treatment period.
喉咽反流患者经常出现与嗓音相关的症状。这是一项前瞻性研究，旨在调查嗓音与药物联合治疗相较于单纯药物治疗，在改善喉咽反流患者嗓音相关症状和参数方面的有效性。在这项前瞻性研究中，总共71名被诊断为伴有嗓音症状的喉咽反流患者被随机分为两组（A组和B组）。A组35名患者仅接受药物治疗，B组36名患者接受药物加嗓音治疗。在治疗前、治疗结束时以及治疗后1个月、2个月记录以下数据：反流症状指数（RSI）、反流发现评分（RFS）、嗓音障碍指数（VHI），并分析嗓音等级、粗糙度、气息声、无力感及紧张度量表（GRBAS）的变化。进行电子喉镜检查以评估疗效。比较两组中这些参数出现临床显著降低的患者数量。在结束时、1个月和2个月的随访评估中，B组有显著更多患者的RSI、VHI和GRBAS评分出现临床显著变化。在结束时或1个月时，两组的RFS均未出现临床显著变化，但在2个月时研究组有显著更大的变化。嗓音治疗可能有助于恢复继发于酸性反流的可逆性黏膜改变，促使症状迅速缓解并缩短治疗周期。
