Wang You-Jie, Shi Xiao-Hong, Li Jia-Xuan, Hong Yan-Long, Wu Fei, Zhao Li-Jie, Feng Yi
Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine under Ministry of Education, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Shanghai Innovation Center of Traditional Chinese Medicine Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zhongguo Zhong Yao Za Zhi. 2018 Dec;43(23):4632-4638. doi: 10.19540/j.cnki.cjcmm.20181105.007.
A new device was designed to measure adhesive force and predict whether traditional Chinese medicine extracts would appear hot-melt sticking in spray drying process．Based on the physical property tester as fundamental test platform, the device was fixed with a camera, a temperature and humidity sensor probe and a set of equipment for hot air. This device could simulate the dry environment of spray dryer and analyze the variables of testing solutions' adhesiveness against drying time. To establish and validate a model of predicting hot-melt sticking in spray drying, data was collected by using data mining. The results of this study proved that the device could be used to predict the hot-melt sticking in spray drying based on the adhesive force of materials (testing solutions). In addition, the study also found that the adhesiveness of the hot-melt sticking materials gradually increased with the evaporation of water, while that of non-sticking materials first increased and then rapidly decreased.
设计了一种新装置来测量粘附力，并预测中药提取物在喷雾干燥过程中是否会出现热熔粘连现象。该装置以物理性能测试仪为基础测试平台，配备了摄像头、温度和湿度传感器探头以及一套热风设备。该装置可以模拟喷雾干燥器的干燥环境，并分析测试溶液的粘附性随干燥时间的变化情况。为了建立和验证喷雾干燥中热熔粘连的预测模型，通过数据挖掘收集数据。本研究结果证明，该装置可根据材料（测试溶液）的粘附力来预测喷雾干燥中的热熔粘连现象。此外，研究还发现，热熔粘连材料的粘附性随着水分的蒸发而逐渐增加，而非粘连材料的粘附性则先增加后迅速下降。
