Salem N, Shingu T, Kim H Y, Hullin F, Bougnoux P, Karanian J W
Section of Analytical Chemistry, DICBR National Institute of Alcohol Abuse and Alcoholism, ADAMHA, Bethesda, Maryland 20892.
Prog Clin Biol Res. 1988;282:319-33.
The principal features of the hypotheses presented here are presented in a model (Figure 8). Polyunsaturated phospholipids are preferentially localized on the cytosolic leaflet of the plasma membrane and around proteins. They influence the physical state of these microenvironments and thereby help to regulate cellular functions. Losses of these species due to phospholipase attack, dietary deprivation or other pathological stimuli (such as alcohol), may lead to drastic alterations in some of these functions. The PUFA's released, including 22:6 omega 3, can be metabolised by a lipoxygenase enzyme in the brain and platelet and the products formed are biologically active.
此处提出的假说的主要特征呈现在一个模型中（图8）。多不饱和磷脂优先定位于质膜的胞质小叶以及蛋白质周围。它们影响这些微环境的物理状态，从而有助于调节细胞功能。由于磷脂酶攻击、饮食缺乏或其他病理刺激（如酒精）导致这些物质的损失，可能会导致其中一些功能发生剧烈改变。释放出的多不饱和脂肪酸，包括22:6 ω-3，可被大脑和血小板中的脂氧合酶代谢，形成的产物具有生物活性。
