Browne Emma, Peeters Frank, Priston Melanie, Marquis P T
British Antarctic Survey Medical Unit, Plymouth, UK.
Centre for Life Sciences (LIFE), Royal Military Academy, Brussels, Belgium.
Wilderness Environ Med. 2019 Mar;30(1):28-34. doi: 10.1016/j.wem.2018.11.003. Epub 2019 Feb 2.
The British Antarctic Survey Medical Unit works in a very remote area of the world, with several Antarctic bases receiving only a single annual resupply of consumable goods. Pharmaceuticals supplied in this manner will often be approaching or past the end of their nominal shelf life before the following year's resupply. Drugs are transported from the UK via ship; the hold is not temperature controlled, and the ship crosses through the tropics (air temperature 25-30°C for approximately 3 wk). The drugs then must be transported from the ship to the base, often in temperatures substantially below freezing. This study assessed the stability of 5 expired drugs (atropine, nifedipine, flucloxacillin, naproxen, and bendroflumethiazide) returned from Antarctic bases.
Drugs were opportunistically obtained and tested using stability-indicating assays.
All tested drugs were stable.
The results suggest that the studied drugs may be stable beyond expiry, even when not maintained in strictly temperature-controlled conditions.
英国南极调查局医疗组在世界上一个非常偏远的地区开展工作，多个南极基地每年仅接收一次消耗品补给。以这种方式供应的药品在次年补给之前往往会接近或超过其标称保质期。药品从英国通过船舶运输；货舱没有温度控制，船舶穿越热带地区（气温约25 - 30°C，持续约3周）。然后这些药品必须从船上运到基地，运输过程中的温度通常会大幅低于冰点。本研究评估了从南极基地返回的5种过期药品（阿托品、硝苯地平、氟氯西林、萘普生和苄氟噻嗪）的稳定性。
利用稳定性指示分析方法，随机获取并测试药品。
所有测试药品均稳定。
结果表明，所研究的药品即使未在严格的温度控制条件下保存，在过期后仍可能保持稳定。
