Faculty of Sciences of Bizerte, Bizerte, Tunisia.
Preparatory Institute for Scientific and Technical Studies, La Marsa, 2075, Tunisia.
Heart Lung Circ. 2020 Feb;29(2):308-314. doi: 10.1016/j.hlc.2018.12.008. Epub 2019 Jan 22.
Thymus algeriensis (T. algeriensis) is traditionally used in Tunisia to treat many human diseases. The aim of the present study was to investigate whether terpenes extracted from the aerial parts of T. algeriensis are potent cardioprotective agents for hydrogen peroxide (HO)-induced cardiotoxicity in rats.
Thirty (30) rats were divided into six groups as per the experimental design: control (n = 6); 0.1 mmol/L HO (LD HO) (n = 6); 1 mmol/L HO (HD HO) (n = 6); oily fraction of T. algeriensis (OFTS) (180 mg/kg b.wt) (n = 6); OFTS + 0.1 mmol/L HO (n = 6); and OFTS + 1 mmol/L HO (n = 6).
The HO demonstrated concentration-dependent cardiotoxic effects in vitro. While, exposure of rats to OFTS significantly depleted HO-induced protein oxidation and lipid peroxidation, it raised antioxidant defence enzymes, and protected against HO-induced histopathological alterations. The antioxidant potential of the thyme essence was assessed by both enzymatic and non-enzymatic antioxidants.
In conclusion, OFTS may be a potential compound for the therapy of oxidative stress-induced heart disease.
阿尔及利亚百里香（T. algeriensis）在突尼斯传统上被用于治疗许多人类疾病。本研究旨在探讨从 T. algeriensis 的地上部分提取的萜类化合物是否对过氧化氢（HO）诱导的大鼠心肌毒性具有强大的心脏保护作用。
根据实验设计，将 30 只大鼠分为六组：对照组（n=6）；0.1mmol/L HO（LD HO）组（n=6）；1mmol/L HO（HD HO）组（n=6）；阿尔及利亚百里香油（OFTS）（180mg/kg b.wt）组（n=6）；OFTS+0.1mmol/L HO 组（n=6）；和 OFTS+1mmol/L HO 组（n=6）。
HO 在体外表现出浓度依赖性的心脏毒性作用。而，暴露于 OFTS 的大鼠显着降低了 HO 诱导的蛋白质氧化和脂质过氧化，提高了抗氧化防御酶的水平，并防止了 HO 诱导的组织病理学改变。通过酶促和非酶促抗氧化剂评估了百里香油的抗氧化潜力。
总之，OFTS 可能是治疗氧化应激诱导的心脏病的潜在化合物。
