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Clinical responses and persistent V600E blood cells in children with LCH treated with MAPK pathway inhibition.

作者信息

Eckstein Olive S, Visser Johannes, Rodriguez-Galindo Carlos, Allen Carl E

机构信息

Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Houston, TX.

Division of Pediatric Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX.

出版信息

Blood. 2019 Apr 11;133(15):1691-1694. doi: 10.1182/blood-2018-10-878363. Epub 2019 Feb 4.

DOI:10.1182/blood-2018-10-878363
PMID:30718231
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6460419/
Abstract
摘要

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Langerhans-Cell Histiocytosis.朗格汉斯细胞组织细胞增多症
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2
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Pediatr Blood Cancer. 2018 Sep;65(9):e27237. doi: 10.1002/pbc.27237. Epub 2018 May 16.
3
CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH-associated neurodegeneration and mass lesions.中枢神经系统朗格汉斯细胞组织细胞增生症：LCH 相关神经退行性变和肿块病变的常见造血起源。
Cancer. 2018 Jun 15;124(12):2607-2620. doi: 10.1002/cncr.31348. Epub 2018 Apr 6.
4
Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties.等位基因特异性激活 MEK1 突变体的机制决定了它们的特性。
Cancer Discov. 2018 May;8(5):648-661. doi: 10.1158/2159-8290.CD-17-1452. Epub 2018 Feb 26.
5
Targeted inhibition of the MAPK pathway: emerging salvage option for progressive life-threatening multisystem LCH.丝裂原活化蛋白激酶（MAPK）通路的靶向抑制：进展性危及生命的多系统朗格汉斯细胞组织细胞增多症新出现的挽救治疗选择
Blood Adv. 2017 Feb 2;1(6):352-356. doi: 10.1182/bloodadvances.2016003533. eCollection 2017 Feb 14.
6
RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions.RAF/MEK/细胞外信号相关激酶通路抑制树突状细胞迁移，并将树突状细胞困在朗格汉斯细胞组织细胞增生症病变中。
J Exp Med. 2018 Jan 2;215(1):319-336. doi: 10.1084/jem.20161881. Epub 2017 Dec 20.
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A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease.红系髓系祖细胞中的体细胞突变会引发神经退行性疾病。
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Targeted therapies in 54 patients with Erdheim-Chester disease, including follow-up after interruption (the LOVE study).针对54例 Erdheim-Chester病患者的靶向治疗，包括中断治疗后的随访（LOVE研究）。
Blood. 2017 Sep 14;130(11):1377-1380. doi: 10.1182/blood-2017-03-771873. Epub 2017 Jun 30.