绿色化学原理在开发一种通过毛细管电泳分析厄他培南钠的新型灵敏方法中的应用。
Application of the Principles of Green Chemistry for the Development of a New and Sensitive Method for Analysis of Ertapenem Sodium by Capillary Electrophoresis.
作者信息
Pedroso Tahisa Marcela, Schepdael Ann Van, Salgado Hérida Regina Nunes
机构信息
UNESP-Univ Estadual Paulista, Faculdade de Ciências Farmacêuticas, Araraquara, São Paulo, Brazil.
KU Leuven-University of Leuven, Department of Pharmaceutical and Pharmacological Sciences, Pharmaceutical Analysis, Leuven, Belgium.
出版信息
Int J Anal Chem. 2019 Jan 2;2019:1456313. doi: 10.1155/2019/1456313. eCollection 2019.
An innovative method is validated for the analysis of ertapenem sodium by capillary electrophoresis using potassium phosphate buffer 10 mM pH 7 and 15 kV voltage, in the concentration range of 70 to 120 g mL. Ertapenem had a migration time of 3.15 minutes and the linearity curve was y = 2281.7 x - 24495 with a R = 0.9994. Thus, we propose a routine analysis method that meets the principles of green analytical chemistry for the routine analysis of ertapenem sodium by capillary electrophoresis.
验证了一种创新方法，用于通过毛细管电泳分析厄他培南钠，使用10 mM pH 7的磷酸钾缓冲液和15 kV电压，浓度范围为70至120 μg/mL。厄他培南的迁移时间为3.15分钟，线性曲线为y = 2281.7x - 24495，R = 0.9994。因此，我们提出了一种符合绿色分析化学原则的常规分析方法，用于通过毛细管电泳对厄他培南钠进行常规分析。
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