Morphological changes in the CNS after Dimer X ventriculography.

The brains of 89 cats were investigated after the stereotactic injection of Dimer X into the ventricular system. The animals were sacrificed after 6, 24 and 48 h and after 7 and 30 days. Morphological changes were found in the ependyma, choroid plexuses, subependymal zone and in the brain tissue. They were most intense within 2 days of the experiment and some lesions (subependymal inflammatory infiltrates and ependymitis granularis) persisted up to 30 days. Similar changes were revealed postmortem in the brains of 20 patients in whom Dimer X ventriculography had been performed.