Rim Chai Hong, Kim Chul Yong, Yang Dae Sik, Yoon Won Sup
Department of Radiation Oncology, Ansan Hospital, Korea University Medical College, Ansan, Gyeonggi-do, Republic of Korea.
Department of Radiation Oncology, Anam Hospital, Korea University Medical College, Seoul, Republic of Korea.
J Cancer. 2019 Jan 1;10(3):682-688. doi: 10.7150/jca.28495. eCollection 2019.
Colorectal cancer is a disease closely associated with anthropometric values. This study aimed to evaluate the clinical relevance of gender and body mass index (BMI) with colorectal cancer using a Korean nationwide cohort. Data of colorectal cancer cohorts between 2012 and 2013 were acquired from the Health Insurance Review and Assessment Service. All patients underwent surgery due to colorectal cancers. Stage IV patients were excluded due to possible clinical heterogeneity. BMI was classified with the World Health Organization criteria. A total of 31,756 patients were analyzed. The underweight group had 33% higher risk of stage III disease (p<0.001). The overweight and obese groups had 20% and 19% lower risk of stage III (p<0.001 and p=0.002, respectively). The underweight and obese groups had higher risk of longest hospitalization period quartile (≥19 days), with odds ratio of 2.26 (p<0.001) and 1.33 (p<0.001), respectively. The overweight group had a 22% lower risk of the longest hospitalization period quartile (p=0.002). Females had 12% lower risk of distal cancer than males (p<0.001). There was no significant relationship between cancer stage and gender. The proportions of patients who were <50 years and ≥70 years old were higher in the females, and the proportions of patients in their 50s and 60s were higher in the males. Cancer stages and hospitalization period varied depending on BMI. Disease location and the age distribution were affected by gender.
结直肠癌是一种与人体测量值密切相关的疾病。本研究旨在利用韩国全国队列评估性别和体重指数（BMI）与结直肠癌的临床相关性。2012年至2013年结直肠癌队列的数据来自健康保险审查和评估服务机构。所有患者均因结直肠癌接受手术。IV期患者因可能存在临床异质性而被排除。BMI根据世界卫生组织标准进行分类。共分析了31756例患者。体重过轻组患III期疾病的风险高33%（p<0.001）。超重和肥胖组患III期疾病的风险分别低20%和19%（分别为p<0.001和p=0.002）。体重过轻和肥胖组住院时间最长四分位数（≥19天）的风险较高，优势比分别为2.26（p<0.001）和1.33（p<0.001）。超重组住院时间最长四分位数的风险低22%（p=0.002）。女性远端癌的风险比男性低12%（p<0.001）。癌症分期与性别之间无显著关系。女性中年龄<50岁和≥70岁的患者比例较高，男性中50多岁和60多岁的患者比例较高。癌症分期和住院时间因BMI而异。疾病部位和年龄分布受性别影响。
