Department of Chemistry, University of Illinois at Chicago, 845 W. Taylor St. MC 111, Chicago, IL 60607, USA.
Chem Commun (Camb). 2019 Feb 19;55(16):2309-2312. doi: 10.1039/c8cc10313e.
A catalyst-controlled cascade reaction has been developed for the synthesis of bridged bicyclic tetrahydrobenz[b]azepin-4-ones from N-arylnitrones and allenes. This method expands the accessible structural diversity of a synthetically challenging heterocyclic scaffold and tunes a catalyst-sensitive process in a new direction.
一种催化剂控制的级联反应已被开发用于从 N-芳基亚硝酮和丙二烯合成桥连双环四氢苯并[b]氮杂卓-4-酮。该方法扩展了具有挑战性的合成杂环支架的可及结构多样性，并为一个对催化剂敏感的过程开辟了新的方向。
