Zalcman S, Minkiewicz-Janda A, Richter M, Anisman H
Psychology Department, Carleton University, Ottawa, Ontario, Canada.
Brain Behav Immun. 1988 Sep;2(3):254-66. doi: 10.1016/0889-1591(88)90027-x.
A series of experiments assessed the effects of stressors on the antibody response in mice. A critical period existed (72 h following antigen administration; sheep red blood cells 10(6) cells, ip) at which footshock reduced the plaque-forming cell (PFC) response in CD-1 mice. When shock was applied at other intervals following immunization (0, 24, 48, or 95 h) the PFC response was unaffected. The immunosuppression was unrelated to the time between stressor application and sacrifice, in that the reduced PFC response was evident both 24 and 48 h after stressor application, and reduced serum antibody titers (IgG) were evident 1 week after stressor exposure. The reduction of the PFC response was dependent on the severity of the stressor, but was not related to stressor controllability, being evident after both escapable and inescapable shock. It appears that stressful events may profoundly influence the immune response but the time between antigen administration and subsequent exposure to a stressor is critical in determining whether such an effect will be evident.
一系列实验评估了应激源对小鼠抗体反应的影响。存在一个关键时期（抗原注射后72小时；腹腔注射10(6)个绵羊红细胞），在此期间，足部电击会降低CD-1小鼠的空斑形成细胞（PFC）反应。当在免疫后的其他时间间隔（0、24、48或95小时）施加电击时，PFC反应不受影响。免疫抑制与应激源施加和处死之间的时间无关，因为在应激源施加后24小时和48小时，PFC反应降低均很明显，并且在应激源暴露1周后血清抗体滴度（IgG）降低也很明显。PFC反应的降低取决于应激源的严重程度，但与应激源的可控性无关，在可逃避和不可逃避的电击后均很明显。看来应激事件可能会深刻影响免疫反应，但抗原注射与随后暴露于应激源之间的时间对于确定这种影响是否会明显至关重要。
