Zalcman S, Richter M, Anisman H
Psychology Department, Carleton University, Ottawa, Ontario, Canada.
Brain Behav Immun. 1989 Jun;3(2):99-109. doi: 10.1016/0889-1591(89)90010-x.
A critical period exists (approximately 72 h) following administration of sheep red blood cells (SRBC) during which inescapable footshock suppressed the peak splenic plaque forming cell (PFC) response and serum antibody titers in CD-1 mice. The immunosuppression was likewise provoked in mice that were exposed to the stressor 2 weeks prior to immunization and reexposed to stressor-related cues 72 h after inoculation. In contrast, when the stressor was initially applied immediately after immunization, reexposure to the stressor-related cues was found to provoke an immunoenhancement. Moreover, stressor exposure immediately following inoculation had the effect of counteracting the immunosuppression otherwise induced by a stressor applied at the 72-h interval. Evidently, environmental cues associated with a stressor provoke profound alterations of immunoresponsiveness, but the direction of the effect is dependent upon the time at which the stressor was initially applied.
在给CD-1小鼠注射绵羊红细胞（SRBC）后的一段时间内（约72小时）存在一个关键期，在此期间，不可逃避的足部电击会抑制脾脏斑块形成细胞（PFC）的峰值反应以及血清抗体滴度。在免疫前2周暴露于应激源且接种后72小时再次暴露于应激源相关线索的小鼠中，同样会引发免疫抑制。相反，当在免疫后立即首次施加应激源时，发现再次暴露于应激源相关线索会引发免疫增强。此外，接种后立即暴露于应激源具有抵消在72小时间隔施加应激源所诱导的免疫抑制的作用。显然，与应激源相关的环境线索会引发免疫反应性的深刻改变，但这种影响的方向取决于首次施加应激源的时间。
