氢化物转移参与的氧化还原中性级联环化反应用于构建具有[3,4]-稠合氧茚部分的螺环双氧吲哚。
Hydride Transfer Involved Redox-Neutral Cascade Cyclizations for Construction of Spirocyclic Bisoxindoles Featuring a [3,4]-Fused Oxindole Moiety.
机构信息
College of Chemistry and Pharmaceutical Sciences , Qingdao Agricultural University , Qingdao 266109 , China.
College of Chemical and Environmental Engineering , Shandong University of Science and Technology , Qingdao 266590 , China.
出版信息
Org Lett. 2019 Feb 15;21(4):1058-1062. doi: 10.1021/acs.orglett.8b04100. Epub 2019 Feb 5.
The hydride transfer involved redox-neutral cascade cyclization has been developed to construct the spirocyclic bisoxindoles featuring a [3,4]-fused oxindole moiety from rationally designed C4-amine-substituted isatins, affording the diverse tricyclic [3,4]-fused oxindoles with three consecutive chiral centers in good yields and excellent diastereoselectivities (>20:1).
涉及氢化物转移的氧化还原中性级联环化已被开发用于构建具有[3,4]-稠合氧吲哚部分的螺环双氧吲哚，从合理设计的 C4-胺取代的色酮出发，以良好的收率和优异的非对映选择性（>20:1）获得多种具有三个连续手性中心的三环[3,4]-稠合氧吲哚。
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