INSERM, UMR 1229, Regenerative Medicine and Skeleton (RMeS), Université de Nantes, École Nationale Vétérinaire, Agroalimentaire et de l'Alimentation, Nantes-Atlantique (ONIRIS), Nantes, France.
Université de Nantes, Unité de Formation et de Recherche (UFR) Odontologie, Nantes, France.
J Bone Miner Res. 2019 Jun;34(6):1101-1114. doi: 10.1002/jbmr.3691. Epub 2019 Mar 19.
Osteoporosis is characterized by low bone mineral density (BMD) and fragility fracture and affects over 200 million people worldwide. Bone quality describes the material properties that contribute to strength independently of BMD, and its quantitative analysis is a major priority in osteoporosis research. Tissue mineralization is a fundamental process requiring calcium and phosphate transporters. Here we identify impaired bone quality and strength in Slc20a2 mice lacking the phosphate transporter SLC20A2. Juveniles had abnormal endochondral and intramembranous ossification, decreased mineral accrual, and short stature. Adults exhibited only small reductions in bone mass and mineralization but a profound impairment of bone strength. Bone quality was severely impaired in Slc20a2 mice: yield load (-2.3 SD), maximum load (-1.7 SD), and stiffness (-2.7 SD) were all below values predicted from their bone mineral content as determined in a cohort of 320 wild-type controls. These studies identify Slc20a2 as a physiological regulator of tissue mineralization and highlight its critical role in the determination of bone quality and strength. © 2019 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc.
骨质疏松症的特征是骨矿物质密度（BMD）低和脆性骨折，影响全球超过 2 亿人。骨质量描述了独立于 BMD 对强度有贡献的材料特性，其定量分析是骨质疏松症研究的主要重点。组织矿化是一个需要钙和磷酸盐转运体的基本过程。在这里，我们在缺乏磷酸盐转运体 SLC20A2 的 Slc20a2 小鼠中发现了骨质量和强度受损。幼年时出现异常的软骨内和膜内成骨，矿化减少，身材矮小。成年人仅表现出骨量和矿化的少量减少，但骨强度严重受损。Slc20a2 小鼠的骨质量严重受损：屈服载荷（-2.3 SD）、最大载荷（-1.7 SD）和刚度（-2.7 SD）均低于根据 320 名野生型对照的骨矿物质含量预测的数值。这些研究确定 Slc20a2 是组织矿化的生理调节剂，并强调了其在确定骨质量和强度方面的关键作用。© 2019 作者。由 Wiley Periodicals Inc. 出版的《骨与矿物研究杂志》
