Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Darwin Building, Gower Street, London, UK.
Database (Oxford). 2019 Jan 1;2019:baz006. doi: 10.1093/database/baz006.
Zinc is one of the most important biologically active metals. Ten per cent of the human genome is thought to encode a zinc binding protein and its uses encompass catalysis, structural stability, gene expression and immunity. At present, there is no specific resource devoted to identifying and presenting all currently known zinc binding sites. Here we present ZincBind, a database of zinc binding sites and its web front-end. Using the structural data in the Protein Data Bank, ZincBind identifies every instance of zinc binding to a protein, identifies its binding site and clusters sites based on 90% sequence identity. There are currently 24 992 binding sites, clustered into 7489 unique sites. The data are available over the web where they can be browsed and downloaded, and via a REST API. ZincBind is regularly updated and will continue to be updated with new data and features.
锌是最重要的生物活性金属之一。据认为，人类基因组的 10%编码一种锌结合蛋白，其用途包括催化、结构稳定性、基因表达和免疫。目前，还没有专门的资源用于识别和呈现所有目前已知的锌结合位点。在这里，我们介绍 ZincBind，这是一个锌结合位点数据库及其网络前端。ZincBind 使用蛋白质数据库中的结构数据，识别蛋白质中每一个锌结合的实例，识别其结合位点，并根据 90%的序列同一性对位点进行聚类。目前有 24992 个结合位点，聚类为 7489 个独特的位点。这些数据可以通过网络浏览和下载，也可以通过 REST API 访问。ZincBind 会定期更新，并将继续更新新的数据和功能。
