Ribes G, Bertrand G, Petit P, Loubatières-Mariani M M
Faculté de Médecine, Unité Associée au CNRS No. 599, Institut de Biologie, Montpellier, France.
Eur J Pharmacol. 1988 Oct 11;155(1-2):171-4. doi: 10.1016/0014-2999(88)90418-9.
The effects of 2-methylthio ATP, an ATP analogue that is more specific for the P2Y receptor, were investigated on insulin secretion in the anesthetized dog in vivo. 2-Methylthio ATP was infused directly into the pancreaticoduodenal artery for 15 min. The infusion was performed so as to obtain a pancreaticoduodenal artery blood level of about 15 microM. 2-Methylthio ATP induced an immediate and significant stimulation of insulin secretion measured from the pancreaticoduodenal vein by means of a T-shaped catheter. After the infusion was stopped, the secretion of insulin progressively decreased and at 30 min was close to basal values. The stimulation of insulin secretion induced a transient but significant reduction of peripheral venous blood glucose levels.
研究了一种对P2Y受体更具特异性的ATP类似物2-甲硫基ATP对麻醉犬体内胰岛素分泌的影响。将2-甲硫基ATP直接注入胰十二指肠动脉15分钟。输注的进行方式是使胰十二指肠动脉血药浓度达到约15微摩尔。通过T形导管从胰十二指肠静脉测量发现，2-甲硫基ATP可立即显著刺激胰岛素分泌。停止输注后，胰岛素分泌逐渐减少，30分钟时接近基础值。胰岛素分泌的刺激导致外周静脉血糖水平短暂但显著降低。
