Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
European Programme for Public Health Microbiology Training (EUPHEM), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
Euro Surveill. 2019 Jan;24(5). doi: 10.2807/1560-7917.ES.2019.24.5.1800159.
Following the rapid increase of infections due to carbapenemase-producing Enterobacteriaceae (CPE) in Italy, the national surveillance of bloodstream infections (BSI) due to CPE ( and ) was instituted in 2013. All CPE-BSI cases reported to the surveillance in the years 2014-17 were analysed in order to investigate incidence rate (IR), trend, main individual characteristics and enzymes involved in CPE resistance. Throughout this period, 7,632 CPE-BSI cases (IR: 3.14/100,000 inhabitants) were reported from all 21 regions and autonomous provinces in Italy, with an increasing number of reported cases (2014: 1,403; 2015: 1,838; 2016: 2,183; 2017: 2,208). CPE-BSI cases mainly occurred in subjects aged over 60 years (70.9%) and more frequently in males (62.7%) than in females. Most of the cases originated in hospitals (87.2%), mainly in intensive care units (38.0%), and were associated with central or peripheral venous catheter use (23.9%) or with urinary tract infections (21.1%). Almost all CPE-BSI (98.1%) were due to carrying the carbapenemase (KPC) enzyme (95.2%). These data show that carbapenemase-producing are endemic in our country, causing a high number of BSI and representing a threat to patient safety.
在意大利产碳青霉烯酶肠杆菌科（CPE）感染迅速增加之后，2013 年建立了全国血流感染（BSI）产碳青霉烯酶肠杆菌科（ 和 ）监测。对 2014-17 年报告给监测的所有 CPE-BSI 病例进行了分析，以调查发病率（IR）、趋势、主要个体特征和参与 CPE 耐药的酶。在此期间，意大利所有 21 个地区和自治区报告了 7632 例 CPE-BSI 病例（IR：3.14/100000 人），报告病例数不断增加（2014 年：1403 例；2015 年：1838 例；2016 年：2183 例；2017 年：2208 例）。CPE-BSI 病例主要发生在 60 岁以上人群（70.9%），男性（62.7%）多于女性（37.3%）。大多数病例起源于医院（87.2%），主要来自重症监护病房（38.0%），与中央或外周静脉导管使用（23.9%）或尿路感染（21.1%）有关。几乎所有的 CPE-BSI（98.1%）都是由 携带的碳青霉烯酶（KPC）引起的（95.2%）。这些数据表明，产碳青霉烯酶的 在我国流行，导致大量 BSI，对患者安全构成威胁。
