FinnBrain Birth Cohort Study, Institute of Clinical Medicine, University of Turku, Turku, Finland; Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
FinnBrain Birth Cohort Study, Institute of Clinical Medicine, University of Turku, Turku, Finland; Department of Child Psychiatry, Turku University Hospital and University of Turku, Turku, Finland.
J Pediatr. 2019 May;208:229-235.e1. doi: 10.1016/j.jpeds.2018.12.050. Epub 2019 Feb 2.
To assess the relation between maternal prenatal psychological distress, comprising depression and anxiety symptoms and relationship quality, and the risk of recurrent respiratory infections (RRIs) in children up to 2 years of age. Children with RRIs frequently use health care services and antibiotics. Prenatal maternal psychological distress can be one, previously unidentified risk factor for RRIs.
The study population was drawn from a population-based pregnancy cohort in Finland (www.finnbrain.fi). Children with RRIs (n = 204) and a comparison group (n = 1014) were identified by maternal reports at the child age of 12 or 24 months. The Edinburgh Postnatal Depression Scale, Symptom Checklist-90 anxiety subscale, the Pregnancy-Related Anxiety Questionnaire-Revised 2, and the Revised Dyadic Adjustment Scale were used to assess maternal symptoms and parental relationship quality at 34 weeks of gestation. Adjustment for maternal postnatal depressive and anxiety symptoms was performed.
Maternal prenatal Edinburgh Postnatal Depression Scale (OR, 1.24; 95% CI, 1.08-1.44), Symptom Checklist-90/Anxiety (OR, 1.40; 95% CI, 1.01-1.76), Pregnancy-Related Anxiety Questionnaire-Revised 2 (OR, 1.28; 95% CI, 1.11-1.47), and Revised Dyadic Adjustment Scale (OR, 1.32; 95% CI, 1.01-1.58) total sum scores were associated with child RRIs by the age of 24 months. Greater number of siblings, shorter duration of breastfeeding, and the level of maternal education were also identified as risk factors for child RRIs.
Maternal prenatal psychological distress is linked with a higher risk for child RRIs.
评估母亲产前心理困扰（包括抑郁和焦虑症状）与关系质量之间的关系，以及它们与 2 岁以下儿童反复呼吸道感染（RRIs）的风险。患有 RRIs 的儿童经常使用医疗保健服务和抗生素。产前母亲心理困扰可能是 RRIs 的一个以前未被识别的风险因素。
该研究人群来自芬兰的一项基于人群的妊娠队列研究（www.finnbrain.fi）。通过在孩子 12 或 24 个月时母亲报告，确定了患有 RRIs（n=204）和对照组（n=1014）的儿童。在妊娠 34 周时，使用爱丁堡产后抑郁量表、症状清单-90 焦虑分量表、修订后的妊娠相关焦虑问卷-2 和修订后的夫妻适应量表评估母亲的症状和父母关系质量。对母亲产后抑郁和焦虑症状进行了调整。
母亲产前爱丁堡产后抑郁量表（OR，1.24；95%CI，1.08-1.44）、症状清单-90/焦虑（OR，1.40；95%CI，1.01-1.76）、修订后的妊娠相关焦虑问卷-2（OR，1.28；95%CI，1.11-1.47）和修订后的夫妻适应量表（OR，1.32；95%CI，1.01-1.58）总分与 24 个月时儿童 RRIs 相关。兄弟姐妹数量较多、母乳喂养时间较短以及母亲教育水平较低也被确定为儿童 RRIs 的风险因素。
母亲产前心理困扰与儿童 RRIs 的风险增加有关。
