Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, China.
Sci Rep. 2019 Feb 5;9(1):1441. doi: 10.1038/s41598-018-37695-0.
With the increasing number of the one-child family, it is important to investigate whether the only-child status is associated with dyslipidemia. Among a national sample of 65,347 Chinese children aged 6-17 years, 16,100 lipid profiles were available. Children's height, weight, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured. In comparison to children with siblings, only children (OC) were more likely to be boys and live in urban areas. OC had less physical activity, less fried food intake, but more meat and dairy intakes. OC had significantly higher levels of TC (3.97 ± 0.78 vs. 3.89 ± 0.77) and LDL-C (2.12 ± 0.65 vs. 2.06 ± 0.64) in the overall group, and also in the subgroups of rural boys and girls. The prevalence of hyper-TC (5.48% vs. 4.43%) and hyper-LDL-C (3.97% vs. 2.96%) were significantly higher in OC than their counterparts. Furthermore, we found higher odds of hyper-LDL-C [1.43 (1.12, 1.83)] in OC after adjustments. In the subgroup analysis, only-child status was associated with increased risk of hyper-TC [1.86 (1.06, 3.26)] and hyper-LDL-C [2.65 (1.14, 6.16)] among rural boys, and hyper-LDL-C among rural girls [2.20 (1.14, 4.22)]. In conclusion, higher levels of TC and LDL-C were found in OC especially for rural children. Being an only-child was associated with increased risk of hyper-LDL-C.
随着独生子女人数的增加，研究独生子女人群是否与血脂异常有关显得尤为重要。在一项对中国 6-17 岁的 65347 名儿童的全国性样本中，有 16100 份血脂谱可供分析。儿童的身高、体重、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）均进行了测量。与有兄弟姐妹的儿童相比，独生子（OC）更可能是男孩，且居住在城市地区。OC 的体育活动较少，摄入的油炸食品较少，但肉类和乳制品的摄入量较多。在整体人群以及农村地区的男童和女童亚组中，OC 的 TC（3.97±0.78 比 3.89±0.77）和 LDL-C（2.12±0.65 比 2.06±0.64）水平显著较高。OC 患高 TC（5.48%比 4.43%）和高 LDL-C（3.97%比 2.96%）的比例也显著高于其对照组。此外，我们发现，调整后 OC 发生高 LDL-C 的几率更高[1.43（1.12，1.83）]。在亚组分析中，仅在农村男童中，OC 与高 TC[1.86（1.06，3.26）]和高 LDL-C[2.65（1.14，6.16）]风险增加相关，在农村女童中，OC 与高 LDL-C[2.20（1.14，4.22）]风险增加相关。综上所述，OC 特别是农村儿童 TC 和 LDL-C 水平较高，且独生子女人群发生高 LDL-C 的风险增加。
