Ludden T M
College of Pharmacy, University of Texas-Austin.
J Clin Pharmacol. 1988 Dec;28(12):1059-63. doi: 10.1002/j.1552-4604.1988.tb05714.x.
The major strength of the population analysis approach is that useful information can be extracted from sparse data using blood samples and pharmacologic monitoring during routine safety and efficacy studies conducted during the development of a drug product. The results of these analyses may lead to integrated pharmacokinetic-pharmacodynamic models that can aid the clinician during the initiation and adjustment of therapeutic regimens. In some cases it may be possible to develop closed-loop control systems that monitor a drug concentration or a response and automatically adjust the drug administration rate. Overall, an increase in the safety and efficiency of drug use can be anticipated.
群体分析方法的主要优势在于，在药品研发过程中进行的常规安全性和有效性研究期间，可通过血样和药理监测从稀疏数据中提取有用信息。这些分析结果可能会形成整合的药代动力学 - 药效学模型，有助于临床医生启动和调整治疗方案。在某些情况下，有可能开发出闭环控制系统，用于监测药物浓度或反应，并自动调整给药速率。总体而言，可以预期药物使用的安全性和效率将会提高。
