Nicole Tran H, Klatsky Arthur L
Department of Medicine, Kaiser Permanente, Oakland, CA, United States of America.
Northern CA Kaiser Permanente, Oakland, CA, United States of America.
Prev Med Rep. 2019 Jan 15;13:268-269. doi: 10.1016/j.pmedr.2019.01.006. eCollection 2019 Mar.
Lower risk of venous thromboembolism in Asians compared to Whites has been suggested. Despite the biological and cultural diversity of Asian Americans, data are sparse for specific ethnic groups. In our prior study of lower Asian American risk, the small number of subjects (337 in all races) precluded accurate study of specific Asian American groups. We present here a new study with 4674 venous thromboembolism subjects diagnosed between 1996 and 2015. Our study population was derived from 61,459 voluntary health examinees in a comprehensive northern California health plan with self-classified ethnicity: 53.0% Whites, 28.4% Blacks, 11.6% ASAMs, 6.8% Others. Of Asian Americans, 44.7% were Chinese, 32.8% Filipinos, 12.9% Japanese, 4.5% South Asians, and 5.0% Other Asians. Chinese, Japanese, Filipinos, and Other Asians each had lower venous thromboembolism risk than both Whites and South Asians, who had risk similar to each other. These data indirectly support a genetic explanation.
与白人相比，亚洲人静脉血栓栓塞风险较低，这一点已得到提示。尽管亚裔美国人存在生物学和文化多样性，但针对特定族裔群体的数据却很稀少。在我们之前关于亚裔美国人风险较低的研究中，受试者数量较少（所有种族共337人），无法对特定亚裔美国人组进行准确研究。我们在此展示一项新研究，该研究纳入了1996年至2015年间诊断的4674例静脉血栓栓塞患者。我们的研究人群来自北加利福尼亚一项综合健康计划中的61459名自愿健康体检者，他们自行分类种族：53.0%为白人，28.4%为黑人，11.6%为亚裔美国人，6.8%为其他种族。在亚裔美国人中，44.7%为中国人，32.8%为菲律宾人，12.9%为日本人，4.5%为南亚人，5.0%为其他亚洲人。中国人、日本人、菲律宾人和其他亚洲人的静脉血栓栓塞风险均低于白人和南亚人，而白人和南亚人的风险彼此相似。这些数据间接支持了一种遗传学解释。
