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双侧肺移植术后儿童发生支气管内镰刀菌病。

Endobronchial fusariosis in a child following bilateral lung transplant.

作者信息

Al Yazidi Laila S, Huynh Julie, Britton Philip N, Morrissey C Orla, Lai Tony, Westall Glen P, Selvadurai Hiran, Kesson Alison

机构信息

Infectious Diseases and Microbiology, The Children's Hospital at Westmead, Sydney, Australia.

The School of Women's and Children's Health, University of New South Wales, New South Wales, Australia.

出版信息

Med Mycol Case Rep. 2019 Jan 14;23:77-80. doi: 10.1016/j.mmcr.2019.01.002. eCollection 2019 Mar.

DOI:10.1016/j.mmcr.2019.01.002
PMID:30723665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6352292/
Abstract

We present a case of endobronchial fusariosis following bilateral sequential lung transplantation for idiopathic pulmonary arterial hypertension in a 13 years old boy who was treated successfully with posaconazole and nebulized amphotericin B. We discuss the role of nebulized amphotericin B in treating invasive pulmonary fungal disease in children. To our knowledge, this is the first pediatric case of endobronchial fusariosis reported in the literature.

摘要

我们报告了一例13岁男孩因特发性肺动脉高压接受双侧序贯肺移植后发生支气管内镰刀菌病的病例,该男孩接受泊沙康唑和雾化两性霉素B治疗成功。我们讨论了雾化两性霉素B在治疗儿童侵袭性肺部真菌病中的作用。据我们所知,这是文献中报道的首例儿童支气管内镰刀菌病病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1150/6352292/b07f44eab560/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1150/6352292/74ba7ebab174/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1150/6352292/b07f44eab560/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1150/6352292/74ba7ebab174/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1150/6352292/b07f44eab560/gr2.jpg

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Endobronchial fusariosis in a child following bilateral lung transplant.双侧肺移植术后儿童发生支气管内镰刀菌病。
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本文引用的文献

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Current antifungal treatment of fusariosis.当前的镰刀菌病抗真菌治疗。
Int J Antimicrob Agents. 2018 Mar;51(3):326-332. doi: 10.1016/j.ijantimicag.2017.06.017. Epub 2017 Jul 10.
2
Therapeutic Drug Monitoring of Posaconazole: an Update.泊沙康唑的治疗药物监测:最新进展
Curr Fungal Infect Rep. 2016;10:51-61. doi: 10.1007/s12281-016-0255-4. Epub 2016 May 7.
3
The 2015 International Society for Heart and Lung Transplantation Guidelines for the management of fungal infections in mechanical circulatory support and cardiothoracic organ transplant recipients: Executive summary.
2015年国际心肺移植学会关于机械循环支持及心胸器官移植受者真菌感染管理的指南:执行摘要
J Heart Lung Transplant. 2016 Mar;35(3):261-282. doi: 10.1016/j.healun.2016.01.007. Epub 2016 Jan 19.
4
Antifungal Prophylaxis in Lung Transplant Recipients.肺移植受者的抗真菌预防
Transplantation. 2016 Sep;100(9):1815-26. doi: 10.1097/TP.0000000000001050.
5
International Evaluation of MIC Distributions and Epidemiological Cutoff Value (ECV) Definitions for Fusarium Species Identified by Molecular Methods for the CLSI Broth Microdilution Method.采用CLSI肉汤微量稀释法通过分子方法鉴定的镰刀菌属菌种的最低抑菌浓度(MIC)分布及流行病学临界值(ECV)定义的国际评估
Antimicrob Agents Chemother. 2015 Dec 7;60(2):1079-84. doi: 10.1128/AAC.02456-15. Print 2016 Feb.
6
10 years of prophylaxis with nebulized liposomal amphotericin B and the changing epidemiology of Aspergillus spp. infection in lung transplantation.雾化脂质体两性霉素B预防治疗10年与肺移植曲霉属感染流行病学的变化
Transpl Int. 2016 Jan;29(1):51-62. doi: 10.1111/tri.12679. Epub 2015 Oct 12.
7
Comparative pharmacodynamics of posaconazole in neutropenic murine models of invasive pulmonary aspergillosis and mucormycosis.泊沙康唑在侵袭性肺曲霉病和毛霉病中性粒细胞减少小鼠模型中的比较药效学。
Antimicrob Agents Chemother. 2014 Nov;58(11):6767-72. doi: 10.1128/AAC.03569-14. Epub 2014 Sep 2.
8
Airway complication contributing to disseminated fusariosis after lung transplantation.肺移植术后导致播散性镰刀菌病的气道并发症。
Transpl Infect Dis. 2014 Aug;16(4):621-4. doi: 10.1111/tid.12240. Epub 2014 Jun 3.
9
Antifungal prophylaxis in pediatric lung transplantation: an international multicenter survey.儿童肺移植中的抗真菌预防:一项国际多中心调查。
Pediatr Transplant. 2014 Jun;18(4):393-7. doi: 10.1111/petr.12263.
10
Fusarium infection in lung transplant patients: report of 6 cases and review of the literature.肺移植患者的镰刀菌感染:6例报告及文献复习
Medicine (Baltimore). 2011 Jan;90(1):69-80. doi: 10.1097/MD.0b013e318207612d.