The Paediatric Integrated Cancer Service, Parkville, Victoria, Australia.
Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Pediatr Blood Cancer. 2019 Jun;66(6):e27634. doi: 10.1002/pbc.27634. Epub 2019 Feb 5.
To date, very few studies have addressed nonneutropenic fever (NNF) in children with cancer, and there are no consensus guidelines. This scoping review aims to describe the rate of bacteremia, risk factors for infection and management, and outcomes of NNF in this population. Across 15 studies (n = 4106 episodes), the pooled-average bacteremia rate was 8.2%, and risk factors included tunneled external central venous catheter, clinical instability, and higher temperature. In two studies, antibiotics were successfully withheld in a subset of low-risk patients. Overall outcomes of NNF appear favorable; however, further research is required to determine its true clinical and economic impact.
迄今为止，很少有研究涉及癌症患儿的非中性粒细胞减少性发热（NNF），也没有共识指南。本范围综述旨在描述该人群中 NNF 的菌血症发生率、感染的危险因素和治疗以及结局。在 15 项研究（n=4106 例）中，菌血症的汇总平均发生率为 8.2%，危险因素包括带隧道的中心静脉置管、临床不稳定和更高的体温。在两项研究中，一组低危患者成功地避免了使用抗生素。NNF 的总体结局似乎较好；然而，需要进一步的研究来确定其对临床和经济的真正影响。
