1 Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, SC, USA.
2 Medical University of South Carolina, Charleston, SC, USA.
Ann Pharmacother. 2019 Jul;53(7):675-682. doi: 10.1177/1060028019828681. Epub 2019 Feb 6.
Dual health system use may provide increased access to physicians, medications, and other health care resources but may also increase the complexity and coordination of medication regimens. Thus, it is important to elucidate the impact of dual use on medication adherence.
The objective of this study was to evaluate the impact on medication adherence for veterans with dual health care system use (VA and Medicare) when obtaining prescription antihyperglycemic medications to treat diabetes.
This was a longitudinal cohort study using VA and Medicare data from 2006 to 2010. Medication adherence was estimated by calculating annualized drug class-level proportion of days covered (PDC), where PDC >80% was considered adherent. Generalized linear models were used for estimations, accounting for correlation over time.
In total, 254 267 veterans with diabetes were included, with 71 057 (27.9%) defined as pharmacy system dual users. Mean age was 77.5 years, and nearly all had multiple comorbidities (mean count 10.2). During follow-up, 75% of VA-only users were deemed adherent to diabetes prescriptions, compared with 63% of dual users. In adjusted models, dual prescription benefit use from VA/Medicare was associated with 39% lower odds of medication adherence (odds ratio [OR] = 0.61; 95% CI = 0.60-0.61). Medication adherence significantly worsened with each additional diabetes medication (OR = 0.65; 95% CI = 0.64-0.65) and significantly decreased over time (OR = 0.95 per year; 95% CI = 0.95-0.96). Conclusion and Relevance: These data suggest that veterans utilizing VA and Medicare to obtain diabetes prescriptions are significantly less likely to be adherent.
双重医疗体系的使用可能会增加患者获得医生、药物和其他医疗资源的机会,但也可能增加药物治疗方案的复杂性和协调性。因此,阐明双重使用对药物依从性的影响很重要。
本研究旨在评估退伍军人在使用双重医疗保健系统(VA 和 Medicare)获得治疗糖尿病的处方抗高血糖药物时,对药物依从性的影响。
这是一项使用 2006 年至 2010 年 VA 和 Medicare 数据的纵向队列研究。通过计算年度药物类别水平的覆盖天数比例(PDC)来估计药物依从性,其中 PDC >80%被认为是依从的。使用广义线性模型进行估计,同时考虑了时间上的相关性。
共有 254267 名患有糖尿病的退伍军人纳入研究,其中 71057 人(27.9%)被定义为药房系统双重使用者。平均年龄为 77.5 岁,几乎所有人都有多种合并症(平均合并症数为 10.2)。在随访期间,75%的仅使用 VA 的患者被认为依从糖尿病处方,而双重使用者的这一比例为 63%。在调整后的模型中,VA/Medicare 的双重处方受益使用与药物依从性降低 39%相关(比值比[OR] = 0.61;95%置信区间[CI] = 0.60-0.61)。药物依从性随着每增加一种糖尿病药物而显著恶化(OR = 0.65;95% CI = 0.64-0.65),并且随着时间的推移显著下降(每年下降 0.95;95% CI = 0.95-0.96)。结论和相关性:这些数据表明,利用 VA 和 Medicare 获得糖尿病处方的退伍军人的药物依从性明显较低。