Department of Chemistry, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, China.
Chem Commun (Camb). 2019 Feb 26;55(18):2616-2619. doi: 10.1039/c8cc09929d.
Here we investigate and reveal the effect of bulge position and bulge identity on G-quadruplexes using label-free spectroscopic techniques. Notably, we report significant differences in the spectroscopic features of bulged DNA and RNA G-quadruplexes, and demonstrate that intrinsic fluorescence can be generally used to detect the formation of canonical and non-canonical G-quadruplexes.
在这里，我们使用无标记光谱技术研究和揭示了凸起位置和凸起身份对 G-四链体的影响。值得注意的是，我们报告了凸起 DNA 和 RNA G-四链体的光谱特征有显著差异，并证明了本征荧光通常可用于检测规范和非规范 G-四链体的形成。
