Social Determinants of Health Research Center, Zanjan Univ. of Medical Sciences, Zanjan, Iran.
Dept. of Food Safety and Hygiene, School of Public Health, Zanjan Univ. of Medical Sciences, Zanjan, Iran.
J Food Sci. 2019 Mar;84(3):695-700. doi: 10.1111/1750-3841.14451. Epub 2019 Feb 6.
Contamination of agricultural commodities with ochratoxin A (OTA) is a worldwide concern in recent decades. Consumption of OTA-contaminated baby foods exerts health implications especially in children as the most vulnerable subpopulations. In the current study, for the first time in Iran, 64 baby foods (rice, wheat, and multigrain) samples from five different brands available in the Iranian market were analyzed to determine OTA level, using a HPLC with fluorescence detector. Overall, OTA was observed in 41% of analyzed samples with a mean and maximum level of 0.42 ± 0.27 and 1.1 μg/kg, respectively. OTA levels in five of 64 samples (7.8 %) were higher than the permissible limit recommended by European Commission (permissible limit: 0.5 μg/kg) and OTA levels in two of 64 samples (3.1%) were higher than the standard set by Iranian standard organization (1 μg/kg). The highest OTA contamination was observed in rice-based baby food cereals (1.1 μg/kg; 57% of the samples), followed by wheat-based (23%) and multigrain (20%) samples. OTA intake in infants (≥9 months old) was more than established provisional tolerable weekly intake by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) and the European Food Safety Authority (EFSA) (100 and 120 ng OTA per kg of body weight, respectively). OTA content in baby food and cereals, as well as other raw foodstuff should be investigated comprehensively to reduce the exposure rate of young children to OTA.
近几十年来，农作物中赭曲霉毒素 A（OTA）的污染是一个全球性的问题。食用受 OTA 污染的婴儿食品对健康有影响，尤其是对儿童这一最脆弱的人群。在本研究中，首次在伊朗对来自伊朗市场上五个不同品牌的 64 种婴儿食品（大米、小麦和多种谷物）样品进行了分析，以使用带有荧光检测器的 HPLC 来确定 OTA 水平。总体而言，在 41%的分析样品中观察到了 OTA，平均和最高水平分别为 0.42 ± 0.27 和 1.1 μg/kg。在 64 个样品中的 5 个（7.8%）中，OTA 水平高于欧盟委员会推荐的允许限量（允许限量：0.5 μg/kg），在 64 个样品中的 2 个（3.1%）中，OTA 水平高于伊朗标准组织设定的标准（1 μg/kg）。在基于大米的婴儿食品谷物中观察到了最高的 OTA 污染（1.1 μg/kg；57%的样品），其次是基于小麦的（23%）和多种谷物的（20%）样品。9 个月以上婴儿的 OTA 摄入量超过了粮农组织/世界卫生组织食品添加剂联合专家委员会（JECFA）和欧洲食品安全局（EFSA）制定的暂定每周可耐受摄入量（100 和 120 ng OTA/kg 体重，分别）。应全面调查婴儿食品和谷物以及其他原料食品中的 OTA 含量，以降低幼儿接触 OTA 的比率。
