El Çiğdem, Şengül Seydi Ahmet
Department of Child Health and Diseases, Tayfur Ata Sökmen Medicine Faculty, Hatay Mustafa Kemal University, 31060 Hatay, Turkey.
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Hatay Mustafa Kemal University, 31060 Hatay, Turkey.
Toxins (Basel). 2025 Jul 25;17(8):366. doi: 10.3390/toxins17080366.
In this study, the aim was to determine the levels of aflatoxins and ochratoxin A (OTA) in baby food consumed in Hatay using fluorescence-detector HPLC (HPLC-FLD) and to reveal the health risks that may occur in babies through consumption of these foods. To determine the dietary intake and to reveal the health risk assessment, the estimated daily intake (EDI) for all mycotoxins, the margin of exposure (MOE) for aflatoxin B (AFB), aflatoxin M (AFM) and OTA, the hazard index (HI) and the consumption-related hepatocellular cancer risk for AFM were calculated. It was reported that 11.5% and 8.2% of the analyzed samples exceeded the legal limit set for AFB and OTA, respectively. However, it was found that AFM concentrations in all samples did not exceed the legal limit. Based on the estimated consumption amounts of the baby foods, the HI values calculated for AFM were below 1, and the MOE values calculated for AFB and AFM were above 10.000, indicating that the consumption of baby foods does not pose a risk regarding AFB and AFM for babies. However, it was determined in all other products, except for toddler formula, that the MOE values calculated for OTA were below 10.000, indicating that their consumption may pose serious health problems in babies.
在本研究中，目的是使用荧光检测器高效液相色谱法（HPLC-FLD）测定哈塔伊地区食用的婴儿食品中黄曲霉毒素和赭曲霉毒素A（OTA）的含量，并揭示婴儿食用这些食品可能产生的健康风险。为了确定膳食摄入量并进行健康风险评估，计算了所有霉菌毒素的估计每日摄入量（EDI）、黄曲霉毒素B（AFB）、黄曲霉毒素M（AFM）和OTA的暴露边际（MOE）、危害指数（HI）以及AFM与消费相关的肝细胞癌风险。据报道，分别有11.5%和8.2%的分析样品超过了AFB和OTA的法定限量。然而，发现所有样品中的AFM浓度均未超过法定限量。根据婴儿食品的估计消费量，计算得出的AFM的HI值低于1，AFB和AFM的MOE值高于10000，这表明婴儿食用婴儿食品不会对AFB和AFM构成风险。然而，除幼儿配方奶粉外，在所有其他产品中确定的OTA的MOE值均低于10000，这表明食用这些产品可能会给婴儿带来严重的健康问题。
