给予海藻酸和戊四氮后大鼠脑中核因子E2相关因子2的表达
Expression of nuclear factor-erythroid 2-related factor 2 in rat brain following the administration of kainic acid and pentylenetetrazole.
作者信息
Ruíz-Díaz Amairani, Manjarrez Joaquín, Nava-Ruíz Concepción, Zaga-Clavellina Verónica, Flores-Espinosa Pilar, Díaz-Ruíz Araceli, Yescas-Gómez Petra, Méndez-Armenta Marisela
机构信息
Experimental Neuropathology Laboratory, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez.
Reticular Formation Laboratory, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez.
出版信息
Neuroreport. 2019 Mar 20;30(5):358-362. doi: 10.1097/WNR.0000000000001207.
Epilepsy is a neurological disorder of the central nervous system characterized by hypersynchronized neuronal activity and has been associated with oxidative stress. Oxidative stress interferes with the expression of genes as well as transcriptional factors such as nuclear factor-erythroid 2-related factor 2 (Nrf2). We evaluated the expression of Nrf2 in the rat brain in treated with kainic acid (KA) and pentylenetetrazole (PTZ). Nrf2 immunoreactivity was observed in astrocytes of the hippocampal region in rats exposed at KA. Nrf2 expression was increased significantly in rats with KA and PTZ. These results provide evidence that the increased expression of Nrf2 is part of the mechanism against KA and PTZ toxicity.
癫痫是一种中枢神经系统的神经疾病，其特征为神经元活动过度同步化，并且与氧化应激有关。氧化应激会干扰基因以及转录因子如核因子红系2相关因子2（Nrf2）的表达。我们评估了用 kainic 酸（KA）和戊四氮（PTZ）处理的大鼠脑中 Nrf2 的表达。在暴露于 KA 的大鼠海马区星形胶质细胞中观察到了 Nrf2 免疫反应性。KA 和 PTZ 处理的大鼠中 Nrf2 表达显著增加。这些结果提供了证据，表明 Nrf2 表达增加是对抗 KA 和 PTZ 毒性机制的一部分。
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