KA和PTZ处理后大鼠脑中金属硫蛋白的表达。

Metallothionein expression in the rat brain following KA and PTZ treatment.

作者信息

Juárez-Rebollar Daniel, Manjarrez Joaquín, Nava-Ruíz Concepción, Zaga-Clavellina Verónica, Flores-Espinosa Pilar, Heras-Romero Yesica, Díaz-Ruíz Araceli, Méndez-Armenta Marisela

机构信息

Lab. Neuropatología Experimental, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Mexico.

Lab. Formación Reticular, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Mexico.

出版信息

Environ Toxicol Pharmacol. 2015 Sep;40(2):530-4. doi: 10.1016/j.etap.2015.08.006. Epub 2015 Aug 10.

DOI:10.1016/j.etap.2015.08.006

PMID:26318565

Abstract

Epilepsy is a neurological disorder that has been associated with oxidative stress therefore epilepsy models have been develop such as kainic acid and pentylenetetrazol are usually used to understanding of the molecular mechanisms of this disease. We examined the metallothionein expression in rat brains of treated with kainic acid and pentylenetetrazol. Increase in metallothionein and nitrotirosyne immunoreactivity of both seizures epilepsy models was observed. Moreover, we show a significant increase on levels of MT expression. These results suggest that the increase of metallothionein expression is related with kainic acid and pentylenetetrazol treatments as response to damage mediated by oxidative stress.

摘要

癫痫是一种与氧化应激相关的神经系统疾病，因此已经开发了癫痫模型，如通常使用 kainic 酸和戊四氮来了解这种疾病的分子机制。我们研究了用 kainic 酸和戊四氮处理的大鼠大脑中金属硫蛋白的表达。在两种癫痫模型中均观察到金属硫蛋白和硝基酪氨酸免疫反应性增加。此外，我们发现 MT 表达水平显著升高。这些结果表明，金属硫蛋白表达的增加与 kainic 酸和戊四氮处理有关，是对氧化应激介导的损伤的反应。