Golin R M, Gotoh E, Said S I, Ganong W F
Department of Physiology, University of California, San Francisco 94143.
Neuropharmacology. 1988 Dec;27(12):1209-13. doi: 10.1016/0028-3908(88)90021-4.
To determine the mechanism by which immobilization and head-up tilt under inactin anesthesia increase plasma renin activity (PRA), the effect of these stimuli on plasma levels of vasoactive intestinal polypeptide (VIP) were measured and the effect of the beta-adrenergic blocking drug, propranolol on the response of plasma renin activity determined. Increases in circulating VIP are known to stimulate secretion of renin. After 10 min of immobilization, plasma renin activity was increased and VIP in plasma was unchanged. After 30 min of tilting, plasma renin activity was also increased and VIP in plasma was unchanged. The increases in plasma renin activity were blocked by propranolol. Inactin anesthesia by itself increased plasma renin activity and this response was unaffected by propranolol and associated with a small decrease, rather than an increase in VIP in plasma. The results indicate that the responses of plasma renin activity to immobilization and head-up tilt are due to increased secretion of renin mediated by the sympathetic nervous system. On the other hand, the increase in secretion of renin produced by inactin anesthesia does not appear to be mediated by the sympathetic nervous system. There was no evidence that VIP was responsible for any of the increases.
为了确定在戊硫代巴比妥麻醉下制动和头高位倾斜增加血浆肾素活性（PRA）的机制，测定了这些刺激对血管活性肠肽（VIP）血浆水平的影响，并确定了β-肾上腺素能阻断药物普萘洛尔对血浆肾素活性反应的影响。已知循环中VIP的增加会刺激肾素分泌。制动10分钟后，血浆肾素活性增加，而血浆中的VIP没有变化。倾斜30分钟后，血浆肾素活性也增加，血浆中的VIP没有变化。血浆肾素活性的增加被普萘洛尔阻断。戊硫代巴比妥麻醉本身会增加血浆肾素活性，这种反应不受普萘洛尔影响，且与血浆中VIP的小幅下降而非增加有关。结果表明，血浆肾素活性对制动和头高位倾斜的反应是由于交感神经系统介导的肾素分泌增加。另一方面，戊硫代巴比妥麻醉引起的肾素分泌增加似乎不是由交感神经系统介导的。没有证据表明VIP与任何增加有关。
