Gotoh E, Golin R M, Ganong W F
Department of Physiology, University of California, San Francisco.
Neuroendocrinology. 1988 Jun;47(6):518-22. doi: 10.1159/000124964.
During an investigation of the role of the mediobasal hypothalamus in the regulation of renin secretion from the kidneys, we found that lesions of the ventromedial nuclei prevented the increase in plasma renin activity produced by p-chloroamphetamine. In the present study, we tested the effects of bilateral electrolytic lesions of the ventromedial nuclei on the increase in plasma renin activity produced in sham-operated rats by immobilization, head-up tilt under inactin anesthesia, and a low-sodium diet. Ventromedial lesions reduced or abolished the plasma renin activity increase to all three stimuli without any change in plasma angiotensinogen. The plasma renin concentration responses to immobilization and a low-sodium diet were also reduced. All these stimuli probably exert their effect by way of the sympathetic nervous system. The data support the hypothesis that the ventromedial nuclei or neural fibers passing through them are important in the renin response to diverse stimuli that act by way of sympathetic discharge.
在一项关于下丘脑内侧基底部在调节肾脏肾素分泌中作用的研究中，我们发现腹内侧核损伤可阻止对氯苯丙胺所引起的血浆肾素活性升高。在本研究中，我们测试了腹内侧核双侧电解损伤对假手术大鼠因固定、戊巴比妥麻醉下头部抬高倾斜以及低钠饮食所引起的血浆肾素活性升高的影响。腹内侧核损伤使对所有这三种刺激的血浆肾素活性升高降低或消失，而血浆血管紧张素原无任何变化。对固定和低钠饮食的血浆肾素浓度反应也降低了。所有这些刺激可能都是通过交感神经系统发挥作用的。这些数据支持这样一种假说，即腹内侧核或穿过它们的神经纤维在肾素对通过交感神经放电起作用的各种刺激的反应中起重要作用。
