Yang Jie, Xiong Liu, Li Man, Xiao Junxia, Geng Xin, Wang Baowei, Sun Qingjie
College of Food Science and Engineering, Qingdao Agricultural University, 700 Changcheng Road, Chengyang District, Qingdao, 266109, China.
Nanoscale Res Lett. 2019 Feb 6;14(1):47. doi: 10.1186/s11671-019-2880-7.
Hemin is a potent iron supplement. A major limitation of the applicability of hemin is its extremely low aqueous solubility and bioavailability. The aim of this work is to prepare hemin nanoparticles with improved solubility. Transmission electron microscopic images showed that hemin nanoparticles with different initial concentrations of hemin (0.1 and 0.5 mg/mL) were tadpole-shaped (head of approximately 200 nm and tail of 100 nm) and sphere-shaped (50-100 nm), respectively. Moreover, hemin nanoparticles exhibited higher solubility than free hemin. The solubility of sphere-shaped nanoparticles was 308.2-fold higher than that of pure hemin at 25 °C. The hemin nanoparticles were stable in acidic conditions and displayed excellent thermal stability. These results suggested that hemin nanoparticles could serve as a potential iron supplement with potential applications in the food, biomedical, and photodynamic-photothermal therapy fields.
血红素是一种有效的铁补充剂。血红素应用的一个主要限制是其极低的水溶性和生物利用度。这项工作的目的是制备具有改善溶解性的血红素纳米颗粒。透射电子显微镜图像显示，初始血红素浓度不同（0.1和0.5mg/mL）的血红素纳米颗粒分别呈蝌蚪状（头部约200nm，尾部100nm）和球形（50-100nm）。此外，血红素纳米颗粒表现出比游离血红素更高的溶解度。在25°C下，球形纳米颗粒的溶解度比纯血红素高308.2倍。血红素纳米颗粒在酸性条件下稳定，并表现出优异的热稳定性。这些结果表明，血红素纳米颗粒可作为一种潜在的铁补充剂，在食品、生物医学和光动力-光热治疗领域具有潜在应用。
