Departments of Bioengineering, Materials Science & Engineering & Beckman Institute, University of Illinois, Urbana, IL 61801, USA.
Mills Breast Cancer Institute, Carle Foundation Hospital, Urbana, IL 61801, USA.
Nanomedicine (Lond). 2020 Oct;15(25):2493-2515. doi: 10.2217/nnm-2020-0125. Epub 2020 Sep 25.
This article is written to provide an up-to-date review of pyrrole-based biomedical materials. Porphyrins and other tetrapyrrolic molecules possess unique magnetic, optical and other photophysical properties that make them useful for bioimaging and therapy. This review touches briefly on some of the synthetic strategies to obtain porphyrin- and tetrapyrrole-based nanoparticles, as well as the variety of applications in which crosslinked, self-assembled, porphyrin-coated and other nanoparticles are utilized. We explore examples of these nanoparticles' applications in photothermal therapy, drug delivery, photodynamic therapy, stimuli response, fluorescence imaging, photoacoustic imaging, magnetic resonance imaging, computed tomography and positron emission tomography. We anticipate that this review will provide a comprehensive summary of pyrrole-derived nanoparticles and provide a guideline for their further development.
本文旨在提供吡咯基生物医学材料的最新综述。卟啉和其他四吡咯分子具有独特的磁、光和其他光物理特性，使其可用于生物成像和治疗。本综述简要介绍了一些获得卟啉和四吡咯基纳米粒子的合成策略，以及交联、自组装、卟啉涂层和其他纳米粒子在各种应用中的应用。我们探讨了这些纳米粒子在光热治疗、药物传递、光动力治疗、刺激响应、荧光成像、光声成像、磁共振成像、计算机断层扫描和正电子发射断层扫描中的应用实例。我们预计，本综述将对吡咯衍生纳米粒子进行全面总结，并为其进一步发展提供指导。
