Brown Kristen N., Hussain Kifah, Richards John R.
Augusta University
Northwestern University
Radiation-induced coronary artery disease (RICAD) is a known cause of morbidity and mortality in patients treated with chest radiation therapy (RT) for cancer but has also been known to occur from other forms of radiation exposure. With the increased use of RT as part of cancer therapy, the rates of RICAD have been increasing in parallel. It is thought to occur due to accelerated atherosclerosis of the coronary vasculature. RICAD affects younger patients, is closely associated with the type of chest RT and radiation dose, and usually affects proximal epicardial coronaries, including left main arterial disease. This article will discuss in detail the etiology of RICAD, epidemiology, clinical presentation, evaluation, screening recommendations, treatment options, differential diagnosis, and complications.
放射性冠状动脉疾病（RICAD）是接受胸部放射治疗（RT）的癌症患者发病和死亡的已知原因，但也已知可由其他形式的辐射暴露引起。随着RT作为癌症治疗一部分的使用增加，RICAD的发生率也在同步上升。它被认为是由于冠状动脉血管的动脉粥样硬化加速所致。RICAD影响年轻患者，与胸部RT的类型和辐射剂量密切相关，通常影响近端心外膜冠状动脉，包括左主干动脉疾病。本文将详细讨论RICAD的病因、流行病学、临床表现、评估、筛查建议、治疗选择、鉴别诊断和并发症。
