Redissi Azza, Penmetsa Gopi K., Litaiem Noureddine
University Of Utah hospital
University of Tunis El Manar
Lupus pernio is a cutaneous manifestation of sarcoidosis, which was first described in 1889 by Ernest Besnier. It presents as a violaceous lesion or shiny nodules over the head and neck but is predominantly localized to the nose, cheeks, and ears. Cutaneous manifestations of sarcoidosis are estimated to occur in approximately 25 percent of patients and the skin lesions help establish the diagnosis of sarcoidosis. Lupus pernio can present either as an isolated skin lesion or it can be an early manifestation of systemic sarcoidosis. Lupus pernio is often a predictor of systemic sarcoidosis, which warrants thorough workup. Patients with lupus pernio have a higher risk for pulmonary disease, which was confirmed in a retrospective study of 516 patients with sarcoidosis. Pulmonary parenchymal involvement was present more often in patients with lupus pernio or sarcoidosis involving scar tissue (64 and 40 percent, respectively) compared to patients with erythema nodosum or other skin lesions of sarcoidosis.
冻疮样狼疮是结节病的一种皮肤表现，于1889年由欧内斯特·贝尼耶首次描述。它表现为头颈部的紫红色病变或发亮结节，但主要局限于鼻子、脸颊和耳朵。据估计，约25%的结节病患者会出现皮肤表现，皮肤病变有助于结节病的诊断。冻疮样狼疮既可以表现为孤立的皮肤病变，也可以是系统性结节病的早期表现。冻疮样狼疮通常是系统性结节病的一个预测指标，这需要进行全面检查。冻疮样狼疮患者患肺部疾病的风险更高，这在一项对516例结节病患者的回顾性研究中得到了证实。与结节性红斑或结节病其他皮肤病变的患者相比，冻疮样狼疮患者或累及瘢痕组织的结节病患者肺部实质受累更为常见（分别为64%和40%）。
