James D G
Royal Free Hospital, London, UK.
Lupus. 1992 May;1(3):129-31. doi: 10.1177/096120339200100302.
Thirty-five patients with lupus pernio have been observed in a series of 818 patients with clinical and histological evidence of sarcoidosis. This analysis provides the natural history of lupus pernio and its associated clinical and radiological features. It predominates in women, and particularly in West Indians. The chronic persistent violaceous skin lesions have a predilection for the nose, cheeks, lips, eyelids, ears and fingers, ranging from a few nodules under the tip of the nose to exuberant plaques spreading across the nose and both cheeks. There was intrathoracic involvement in 74% of patients, upper respiratory tract disease in 54%, reticulo-endothelial involvement in 54%, bone cysts in 43% and ocular lesions in 37%. It is distinguished from lupus vulgaris and lupus erythematosus by clinical features, histology and radiology.
在818例有结节病临床及组织学证据的患者中，观察到35例患有冻疮样狼疮。该分析提供了冻疮样狼疮的自然病史及其相关的临床和放射学特征。它在女性中占主导，尤其是在西印度人中。慢性持续性紫红色皮肤病变好发于鼻、脸颊、嘴唇、眼睑、耳朵和手指，从鼻尖下的几个结节到蔓延至鼻和双颊的增生性斑块不等。74%的患者有胸腔受累，54%有上呼吸道疾病，54%有网状内皮系统受累，43%有骨囊肿，37%有眼部病变。它通过临床特征、组织学和放射学与寻常狼疮和红斑狼疮相鉴别。
