Tănăsescu C, Petrea S, Băldescu R, Macarie E, Chiriloiu C, Purice S
N. Gh. Lupu Institute of Internal Medicine, Bucharest, Romania.
Med Interne. 1988 Oct-Dec;26(4):311-22.
The Romanian product Silimarina (synonym Legalon) was administered in a randomized double-blind trial, to a group of 180 patients with chronic persistent hepatitis (CPH), chronic active hepatitis (CAH) and hepatic cirrhosis (HC). The trial lasted for 40 days. The results showed favourable effects similar with those obtained with other preparations produced by foreign drug industries. The Romanian product proved to have no toxic effect. The authors discuss the present possibilities of estimating the evolution of chronic liver disease.
罗马尼亚产品水飞蓟宾葡甲胺片(商品名利加隆)在一项随机双盲试验中,被用于一组180例慢性持续性肝炎(CPH)、慢性活动性肝炎(CAH)和肝硬化(HC)患者。试验持续了40天。结果显示,其产生的良好效果与国外制药行业生产的其他制剂相似。该罗马尼亚产品被证明没有毒性作用。作者讨论了目前评估慢性肝病病情发展的可能性。