Kiesewetter E, Leodolter I, Thaler H
Leber Magen Darm. 1977 Oct;7(5):318-23.
In two double-blind studies with 24 and 12 patients, respectively, the effect of silymarine on chronic hepatitis was studied. The treatment lasted three months to one year. In the laboratory tests investigated no remarkable difference between silymarine and placebo therapy was seen. Some histological changes, however, were improved under silymarine, one of them significantly. A control of these findings will be necessary. The question arises if silymarine occupies receptors on the liver cell membrane and therefore causes a partial blocking of immunologic reactions. The difficulties of prospective studies in chronic liver disease are emphasized.
分别在两项针对24名和12名患者的双盲研究中，研究了水飞蓟宾对慢性肝炎的疗效。治疗持续了三个月至一年。在所进行的实验室检测中，未发现水飞蓟宾与安慰剂治疗之间存在显著差异。然而，在水飞蓟宾治疗下，一些组织学变化有所改善，其中一项改善显著。有必要对这些结果进行对照验证。问题在于水飞蓟宾是否占据肝细胞膜上的受体，从而导致免疫反应的部分阻断。强调了在慢性肝病中进行前瞻性研究的困难。
