调控性 T 细胞受制于线粒体。
Regulatory T Cells under the Mercy of Mitochondria.
机构信息
Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Descartes, Sorbonne Paris Cité, Paris F-75006, France.
出版信息
Cell Metab. 2019 Feb 5;29(2):243-245. doi: 10.1016/j.cmet.2019.01.012.
Mitochondria, the powerhouse of the cell, known for producing energy through oxidative phosphorylation and the Krebs cycle, continue gaining notoriety for roles beyond bioenergetics. Recently in Nature, Weinberg et al. (2019) reported that mitochondrial complex III is indispensable for suppressive function of regulatory T cells, thus highlighting the importance of mitochondria in immune tolerance.
线粒体，细胞的能量工厂，以通过氧化磷酸化和三羧酸循环产生能量而闻名，现在又因其在生物能量学之外的作用而声名狼藉。最近，Weinberg 等人在《自然》杂志上报道（2019 年），线粒体复合物 III 对于调节性 T 细胞的抑制功能是不可或缺的，从而强调了线粒体在免疫耐受中的重要性。
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