色素上皮衍生因子影响腹腔疾病中的血管生成。
Pigment Epithelium-Derived Factor Affects Angiogenesis in Celiac Disease.
机构信息
Department of Gastroenterology, Department of Medical Biochemistry, Kecioren Training and Research Hospital, Ankara, Turkey,
Department of Gastroenterology, Department of Medical Biochemistry, Kecioren Training and Research Hospital, Ankara, Turkey.
出版信息
Med Princ Pract. 2019;28(3):236-241. doi: 10.1159/000497612. Epub 2019 Feb 6.
OBJECTIVE
Recent studies have demonstrated that angiogenesis is impaired in patients with celiac disease (CD). In this study, we evaluated the levels of the novel antiangiogenic factor pigment epithelium-derived factor (PEDF) in CD patients.
METHODS
Eighty-four patients were included in the study; 71 patients with CD and 13 healthy controls. In the CD patient cohort, there were 21 newly diagnosed patients, 19 with adherence to a gluten-free diet and 31 practicing no adherence to this diet. The PEDF levels were measured using enzyme-linked immunosorbent assays.
RESULTS
The data revealed that celiac patients had higher levels of PEDF than did healthy controls. PEDF levels were not significantly different among the three CD groups. Additionally, the PEDF levels were not correlated with tissue transglutaminase IgA or IgG.
CONCLUSIONS
Our data indicate that PEDF levels are significantly higher in CD patients than those in the healthy controls. This result suggests that PEDF negatively affects angiogenesis in CD. Although we did not observe any differences of PEDF levels among celiac patients, additional studies including more patients could clarify this issue.
目的
最近的研究表明，乳糜泻（CD）患者的血管生成受损。在这项研究中，我们评估了新型抗血管生成因子色素上皮衍生因子（PEDF）在 CD 患者中的水平。
方法
本研究纳入了 84 名患者；71 名 CD 患者和 13 名健康对照者。在 CD 患者队列中，有 21 名新诊断的患者，19 名遵守无麸质饮食，31 名不遵守无麸质饮食。使用酶联免疫吸附测定法测量 PEDF 水平。
结果
数据显示，乳糜泻患者的 PEDF 水平高于健康对照组。三组 CD 患者之间 PEDF 水平无显著差异。此外，PEDF 水平与组织转谷氨酰胺酶 IgA 或 IgG 无关。
结论
我们的数据表明，CD 患者的 PEDF 水平明显高于健康对照组。这一结果表明 PEDF 负向影响 CD 中的血管生成。尽管我们没有观察到乳糜泻患者之间 PEDF 水平有任何差异，但包括更多患者的进一步研究可以阐明这一问题。
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