文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

CXCR3 和 CCR6 在具有不同记忆表型的 CD4 T 淋巴细胞上的差异表达特征性地表征了与结核相关的免疫重建炎症综合征。

Differential expression of CXCR3 and CCR6 on CD4 T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome.

机构信息

Instituto Gonçalo Moniz, Salvador, Bahia, Brazil.

Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Fundação José Silveira, Salvador, Bahia, Brazil.

出版信息

Sci Rep. 2019 Feb 6;9(1):1502. doi: 10.1038/s41598-018-37846-3.

DOI:10.1038/s41598-018-37846-3
PMID:30728405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6365576/
Abstract

Immune reconstitution inflammatory syndrome (IRIS) occurs in up to 40% of individuals co-infected with pulmonary tuberculosis (PTB) and HIV, primarily upon antiretroviral therapy (ART) initiation. Phenotypic changes in T-cells during TB-IRIS and their relationship with systemic inflammation are not fully understood. In this prospective cohort study, we followed 48 HIV-positive patients with PTB from South India before and after ART initiation, examining T-lymphocyte subsets and inflammatory biomarkers in peripheral blood. Quantification of naïve (CD27CD45RO) as well as effector memory CD4 T cells (CD27CD45RO) at weeks 2-6 after ART initiation could distinguish TB-IRIS from non-IRIS individuals. Additional analyses revealed that ART reconstituted different quantities of CD4 T lymphocyte subsets with preferential expansion of CXCR3 CCR6 cells in TB-IRIS patients. Moreover, there was an expansion and functional restoration of central memory (CD27CD45RO) CXCR3CCR6 CD4 lymphocytes and corresponding cytokines, with reduction in CXCR3CCR6 cells after ART initiation only in those who developed TB-IRIS. Together, these observations trace a detailed picture of CD4 T cell subsets tightly associated with IRIS, which may serve as targets for prophylactic and/or therapeutic interventions in the future.

摘要

免疫重建炎症综合征 (IRIS) 可发生于高达 40%的合并肺结核 (PTB) 和 HIV 感染的个体中，主要发生在抗逆转录病毒治疗 (ART) 开始时。在 TB-IRIS 期间 T 细胞的表型变化及其与全身炎症的关系尚未完全阐明。在这项前瞻性队列研究中，我们在 ART 开始前后随访了来自印度南部的 48 名 HIV 阳性合并肺结核患者，检测外周血中的 T 淋巴细胞亚群和炎症生物标志物。在 ART 开始后 2-6 周定量检测 naïve（CD27CD45RO）和效应记忆 CD4 T 细胞（CD27CD45RO）可以区分 TB-IRIS 与非 IRIS 个体。进一步的分析表明，ART 重建了不同数量的 CD4 T 淋巴细胞亚群，TB-IRIS 患者中 CXCR3 CCR6 细胞优先扩增。此外，在那些发生 TB-IRIS 的患者中，中央记忆（CD27CD45RO）CXCR3CCR6 CD4 淋巴细胞及其相应细胞因子扩增和功能恢复，而仅在那些发生 TB-IRIS 的患者中，CXCR3CCR6 细胞在 ART 开始后减少。总之，这些观察结果描绘了与 IRIS 密切相关的 CD4 T 细胞亚群的详细情况，这些亚群可能成为未来预防和/或治疗干预的靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/769e/6365576/c6dd580b37da/41598_2018_37846_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/769e/6365576/c45f9f7e8e76/41598_2018_37846_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/769e/6365576/85748f011e15/41598_2018_37846_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/769e/6365576/3695f8a5a936/41598_2018_37846_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/769e/6365576/d2277385904d/41598_2018_37846_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/769e/6365576/c6dd580b37da/41598_2018_37846_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/769e/6365576/c45f9f7e8e76/41598_2018_37846_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/769e/6365576/85748f011e15/41598_2018_37846_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/769e/6365576/3695f8a5a936/41598_2018_37846_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/769e/6365576/d2277385904d/41598_2018_37846_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/769e/6365576/c6dd580b37da/41598_2018_37846_Fig5_HTML.jpg

相似文献

[1]
Differential expression of CXCR3 and CCR6 on CD4 T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome.

Sci Rep. 2019-2-6

[2]
Robust Reconstitution of Tuberculosis-Specific Polyfunctional CD4+ T-Cell Responses and Rising Systemic Interleukin 6 in Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome.

Clin Infect Dis. 2016-3-15

[3]
Frequency of CXCR3 CD8 T-Lymphocyte Subsets in Peripheral Blood Is Associated With the Risk of Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Development in Advanced HIV Disease.

Front Immunol. 2022

[4]
Dynamics of T-Lymphocyte Activation Related to Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome in Persons With Advanced HIV.

Front Immunol. 2021

[5]
Changes in the NK Cell Repertoire Related to Initiation of TB Treatment and Onset of Immune Reconstitution Inflammatory Syndrome in TB/HIV Co-infected Patients in Rio de Janeiro, Brazil-ANRS 12274.

Front Immunol. 2019-8-13

[6]
Immunological profiling of tuberculosis-associated immune reconstitution inflammatory syndrome and non-immune reconstitution inflammatory syndrome death in HIV-infected adults with pulmonary tuberculosis starting antiretroviral therapy: a prospective observational cohort study.

Lancet Infect Dis. 2015-4

[7]
Lower Pre-Treatment T Cell Activation in Early- and Late-Onset Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome.

PLoS One. 2015-7-24

[8]
The immunopathogenesis of the HIV tuberculosis immune reconstitution inflammatory syndrome.

Eur J Immunol. 2013-8

[9]
Skewing of the CD4(+) T-cell pool toward monofunctional antigen-specific responses in patients with immune reconstitution inflammatory syndrome in The Gambia.

Clin Infect Dis. 2013-5-3

[10]
Immunological characterisation of an unmasking TB-IRIS case.

S Afr Med J. 2012-3-2

引用本文的文献

[1]
Chikungunya virus-specific CD4 T cells are associated with chronic chikungunya viral arthritic disease in humans.

Cell Rep Med. 2025-5-20

[2]
T Cell Homeostasis Disturbances in a Cohort of Long-Term Elite Controllers of HIV Infection.

Int J Mol Sci. 2024-5-29

[3]
CD4 T cells are homeostatic regulators during reinfection.

bioRxiv. 2023-12-21

[4]
Natural Killer Repertoire Restoration in TB/HIV Co-Infected Individuals Experienced an Immune Reconstitution Syndrome (CAMELIA Trial, ANRS 12153).

Pathogens. 2023-10-13

[5]
TRAV26-2 T-Cell Receptor Expression Is Associated With Mucosal Lymphocyte Response to Wheat Proteins in Patients With Functional Dyspepsia.

Clin Transl Gastroenterol. 2023-12-1

[6]
Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome-An Extempore Game of Misfiring with Defense Arsenals.

Pathogens. 2023-1-29

[7]
Phenotypic Profile of -Specific CD4 T-Cell Responses in People With Advanced Human Immunodeficiency Virus Who Develop Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome.

Open Forum Infect Dis. 2022-10-17

[8]
Type 2 and type 17 effector cells are increased in the duodenal mucosa but not peripheral blood of patients with functional dyspepsia.

Front Immunol. 2022

[9]
Frequency of CXCR3 CD8 T-Lymphocyte Subsets in Peripheral Blood Is Associated With the Risk of Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Development in Advanced HIV Disease.

Front Immunol. 2022

[10]
Antiretroviral therapy timing impacts latent tuberculosis infection reactivation in a Mycobacterium tuberculosis/SIV coinfection model.

J Clin Invest. 2022-2-1

本文引用的文献

[1]
Unique Action of Interleukin-18 on T Cells and Other Immune Cells.

Front Immunol. 2018-4-20

[2]
Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells.

AIDS Res Ther. 2018-3-15

[3]
Daily vs Intermittent Antituberculosis Therapy for Pulmonary Tuberculosis in Patients With HIV: A Randomized Clinical Trial.

JAMA Intern Med. 2018-4-1

[4]
T follicular helper cells regulate the activation of B lymphocytes and antibody production during Plasmodium vivax infection.

PLoS Pathog. 2017-7-10

[5]
Risk factors and frequency of tuberculosis-associated immune reconstitution inflammatory syndrome among HIV/Tuberculosis co-infected patients in Southern India.

Indian J Med Microbiol. 2017

[6]
Aberrant Inflammasome Activation Characterizes Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome.

J Immunol. 2016-5-15

[7]
Robust Reconstitution of Tuberculosis-Specific Polyfunctional CD4+ T-Cell Responses and Rising Systemic Interleukin 6 in Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome.

Clin Infect Dis. 2016-3-15

[8]
Lower Pre-Treatment T Cell Activation in Early- and Late-Onset Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome.

PLoS One. 2015-7-24

[9]
Plasma interleukin-18 levels are a biomarker of innate immune responses that predict and characterize tuberculosis-associated immune reconstitution inflammatory syndrome.

AIDS. 2015-2-20

[10]
TB-IRIS, T-cell activation, and remodeling of the T-cell compartment in highly immunosuppressed HIV-infected patients with TB.

AIDS. 2015-1-28

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索