急性尿毒症大鼠肌肉蛋白分解代谢的激素调节：肾上腺切除术和甲状旁腺切除术的影响。
Hormonal regulation of muscle protein catabolism in acutely uremic rats: effect of adrenalectomy and parathyroidectomy.
作者信息
Schaefer R M, Moser M, Kulzer P, Peter G, Heidland A, Hörl W H, Massry S G
机构信息
Department of Internal Medicine, University of Wuerzburg, FRG.
出版信息
Adv Exp Med Biol. 1988;240:257-66. doi: 10.1007/978-1-4613-1057-0_30.
To examine the role of glucocorticoids and PTH on the enhanced protein catabolism of acute uremia, rats were rendered uremic and had their adrenals or their parathyroid glands concomitantly removed. Adrenalectomy resulted in a marked reduction of urea generation in uremic animals due to decrease of myofibrillar protein breakdown as indicated by lower serum levels of Nt-methylhistidine and a reduction in the activity of the myofibrillar proteinase from skeletal muscle. This reduced urea formation was accompanied by marked hypoglycemia. Parathyroidectomy, on the other hand, caused no change of those parameters of protein catabolism, suggesting that PTH does not account for the protein degradation observed in acutely uremic rats.
为研究糖皮质激素和甲状旁腺激素（PTH）在急性尿毒症时蛋白质分解代谢增强中的作用，将大鼠制成尿毒症模型，并同时切除其肾上腺或甲状旁腺。肾上腺切除导致尿毒症动物尿素生成显著减少，这是由于肌原纤维蛋白分解减少所致，表现为血清Nt-甲基组氨酸水平降低以及骨骼肌肌原纤维蛋白酶活性降低。尿素生成减少伴随着明显的低血糖。另一方面，甲状旁腺切除并未引起蛋白质分解代谢这些参数的变化，这表明PTH并非急性尿毒症大鼠中观察到的蛋白质降解的原因。
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