乌脚病患者血管内皮中前列环素的产生

Prostacyclin production in vascular endothelium of patients with Blackfoot disease.

作者信息

Mak O T

机构信息

Department of Biology, National Cheng Kung University, Tainan, Taiwan, Republic of China.

出版信息

Adv Exp Med Biol. 1988;242:119-25. doi: 10.1007/978-1-4684-8935-4_14.

DOI:10.1007/978-1-4684-8935-4_14

PMID:3072861

Abstract

The levels of 6-keto-PGF1 alpha and TXB2 were determined by the RIA method in Blackfoot disease which is an endemic disease of the peripheral vascular system found in the southwest coast of Taiwan. The level of TXB2 was normal, but that of 6-keto-PGF2 alpha concentration was 30% lower than the normal. The activity of 15-hydroxyprostaglandin dehydrogenase was higher in patients' blood plasma than in the normal. Patient's vascular endothelium was also found to have lower prostacyclin synthase activity. These results suggest that the reduced prostacyclin production in vascular endothelium contributes to the pathogenesis of Blackfoot disease.

摘要

采用放射免疫分析法（RIA法）测定了台湾西南海岸发现的一种外周血管系统地方病——乌脚病患者体内6-酮-前列腺素F1α（6-keto-PGF1α）和血栓素B2（TXB2）的水平。TXB2水平正常，但6-酮-前列腺素F2α（6-keto-PGF2α）浓度比正常水平低30%。患者血浆中15-羟基前列腺素脱氢酶的活性高于正常人。还发现患者血管内皮的前列环素合酶活性较低。这些结果表明，血管内皮中前列环素生成减少是乌脚病发病机制的一个因素。