Alterations in gastric mucosal microvascular endothelium in a stressed condition--relevance to gastric ulcerogenesis.
作者信息
Oda M, Nakamura M, Honda K, Komatsu H, Kaneko K, Azuma T, Suematsu M, Yonei Y, Watanabe N, Tsuchiya M
机构信息
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
出版信息
Adv Exp Med Biol. 1988;242:161-75. doi: 10.1007/978-1-4684-8935-4_19.
The present paper describes the morphological and functional alterations of the gastric mucosal microvascular endothelium under restraint-stressed condition. On the basis of the direct cholinergic innervation of capillaries and non-muscular venules in the gastric mucosa, these endothelial changes would be caused by the stress-induced overstimulation of the cholinergic nerves and modified by the degranulation of mast cells, contributing to the stress-induced ulcer formation as schematically illustrated in Fig. 10.
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