Anomalies in MiRNAs Machinery Gene, GEMIN-4 Variants Suggest Renal Cell Carcinoma Risk: A Small Experimental Study from North India.

is a member of the gene family which is involved in multiple pathologies including cancer. It is located on Chr17p13.3, the most notorious chromosome and a hotspot for various carcinomas. We therefore intend to find genetic variants of gene associated with renal cell carcinoma risk (RCC). This study comprised 100 patients and 225 controls. Genotyping of gene variants was done using Taqman assay. The association of variants and risk prediction of RCC was done by statistical analysis. Haplotype analysis was done to see the combined effect of variants on RCC. Patients carrying variant genotype, CC of T/C rs7813 showed significant association whereas in case of G/C rs910925 variant genotype, CC significant risk was found. rs7813 T/C variant genotype, CC showed risk with smoking ( = 0.034). Our study gives a substantive support for the association between the gene variants and RCC risk.