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[成人斯蒂尔病的肝脏表现]

[Hepatic manifestations in Still's disease].

作者信息

Algayres J P, Daly J P, Oddes B, Valmary J, Halna du Fretay X, Maurel C, Thomas A, Chabierski M, Larroque P, Laverdant C

机构信息

Clinique Médicale, Hôpital d'Instruction des Armées du Valde-Grâce, Paris.

出版信息

Ann Med Interne (Paris). 1988;139(7):476-81.

PMID:3072893
Abstract

In children, as in adults, Still's disease usually presents with a hectic fever, a characteristic rash and arthralgia or arthritis. Visceral involvement is however classical; the hepatic manifestations were studied with respect to two cases. Biochemical changes are common, often mild: the commonest abnormality is cytolysis. Jaundice is less frequent and hepatic involvement may in exceptional cases be life threatening, usually in cases of serious polyvisceral disease often with disseminated intravascular coagulation. These manifestations may be spontaneous or secondary to salicylate therapy; the anatomical changes are the same; the salicylate would therefore seem rather to unmask and aggravate an underlying hepatic abnormality.

摘要

与成人一样,儿童的斯蒂尔病通常表现为弛张热、特征性皮疹以及关节痛或关节炎。然而,内脏受累较为典型;针对两例病例对肝脏表现进行了研究。生化改变很常见,通常较轻:最常见的异常是细胞溶解。黄疸较少见,在极少数情况下肝脏受累可能危及生命,通常发生在严重多脏器疾病且常伴有弥散性血管内凝血的病例中。这些表现可能是自发的,也可能继发于水杨酸盐治疗;解剖学改变相同;因此水杨酸盐似乎更像是揭示并加重了潜在的肝脏异常。

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[Hepatic manifestations in Still's disease].[成人斯蒂尔病的肝脏表现]
Ann Med Interne (Paris). 1988;139(7):476-81.
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