Lee Lisa Eunyoung, Chan Jillian K, Nevill Emilie, Soares Adam, Vavasour Irene M, MacMillan Erin L, Garren Hideki, Clayton David, Keegan B Mark, Tam Roger, Traboulsee Anthony L, Kolind Shannon H, Carruthers Robert L
Department of Medicine (Neurology), University of British Columbia, Canada.
Department of Radiology, University of British Columbia, Canada.
Mult Scler J Exp Transl Clin. 2019 Jan 16;5(1):2055217318824612. doi: 10.1177/2055217318824612. eCollection 2019 Jan-Mar.
Progressive solitary sclerosis is a unifocal demyelinating disease recently proposed as a possible multiple sclerosis variant.
To compare myelin content and brain metabolite ratio qualitatively in the normal-appearing white matter of progressive solitary sclerosis cases compared to multiple sclerosis and healthy control participants.
Case report.
Progressive solitary sclerosis cases showed abnormal myelin in normal-appearing white matter tracts and global normal-appearing white matter as well as lower N-acetyl-aspartate to total creatine ratio compared to multiple sclerosis and healthy control groups.
Despite a single demyelinating lesion along the corticospinal tract in progressive solitary sclerosis, we showed evidence of more extensive abnormality within the normal-appearing white matter.
进行性孤立性硬化症是一种单灶性脱髓鞘疾病，最近被提出可能是多发性硬化症的一种变体。
比较进行性孤立性硬化症患者与多发性硬化症患者及健康对照者正常外观白质中的髓磷脂含量和脑代谢物比率。
病例报告。
与多发性硬化症组和健康对照组相比，进行性孤立性硬化症患者在正常外观的白质束和整体正常外观白质中显示出异常的髓磷脂，且N-乙酰天门冬氨酸与总肌酸的比率较低。
尽管进行性孤立性硬化症患者沿皮质脊髓束有单个脱髓鞘病变，但我们发现其正常外观白质内存在更广泛异常的证据。
