Ejeta Eyasu, Dabsu Regea
Department of Medical Laboratory Sciences, College of Medical and Health Sciences, Wollega University, Nekemte, Ethiopia.
Department of Medical Laboratory Sciences and Pathology, College Health Sciences, Jimma University, Jimma, Ethiopia.
Front Med (Lausanne). 2019 Jan 23;5:366. doi: 10.3389/fmed.2018.00366. eCollection 2018.
and HIV infection remain a major public health challenge in Sub-Saharan Africa. The HCV and HIV infection among pregnant women have a serious outcome on maternal and newborn health. There is limited information in this regards in West part of Ethiopia. This study aims to identify the sero- prevalence and predictor factors of HCV and HIV infection among pregnant women attending antenatal care (ANC) in Western Ethiopia. An institutional based cross-sectional study was conducted from July to September, 2014 among 421 pregnant women's attending ANC services in purposively selected health facilities of western Ethiopia. The HCV and HIV infections were diagnosed by detection antibodies from aseptically collected serum sample. HCV was identified using an enzyme linked immune sorbent assay (ELISA) while HIV infection was tested with rapid HIV tests following the national HIV test algorithm. The pretested and structured questionnaire was used to collect socio-demographic data, and potential predictor factors of HCV and HIV infection. The collected data were analyzed using SPSS version 20.0 statistical software. The overall sero-prevalence of HCV and HIV among the study population was 8.1% and 1.0%, respectively. The prevalence of HCV/HIV co-infection was 0.23% (1/421). Among HIV infected women, the prevalence of HCV infection was 25% (1/4). The risk of HCV infection was significantly low for urban residents (AOR = 0.38, 95%CI: 0.16-0.90) and illiterate (AOR = 0.24, 95%CI: 0.06-0.85). However, the history of blood transfusion was significantly increases the risk of HIV infection (AOR = 19.52, 95%CI: 1.80-150.6). Our study confirms public health importance of HCV and HIV infections among pregnant women in the study area. The study suggests need of attention for rural residents and educated segment of the population for HCV prevention, and national blood blank to check HIV test method used for blood transfusion.
在撒哈拉以南非洲，丙型肝炎病毒（HCV）感染和人类免疫缺陷病毒（HIV）感染仍然是一项重大的公共卫生挑战。孕妇中的HCV和HIV感染对孕产妇和新生儿健康会产生严重后果。在埃塞俄比亚西部，这方面的信息有限。本研究旨在确定埃塞俄比亚西部接受产前护理（ANC）的孕妇中HCV和HIV感染的血清流行率及预测因素。2014年7月至9月，在埃塞俄比亚西部经过有目的选择的医疗机构中，对421名接受ANC服务的孕妇开展了一项基于机构的横断面研究。通过检测无菌采集的血清样本中的抗体来诊断HCV和HIV感染。使用酶联免疫吸附测定（ELISA）鉴定HCV，而按照国家HIV检测算法，用HIV快速检测法检测HIV感染。采用预先测试并结构化的问卷收集社会人口统计学数据以及HCV和HIV感染的潜在预测因素。使用SPSS 20.0版统计软件对收集的数据进行分析。研究人群中HCV和HIV的总体血清流行率分别为8.1%和1.0%。HCV/HIV合并感染率为0.23%（1/421）。在感染HIV的女性中，HCV感染率为25%（1/4）。城市居民（调整后比值比[AOR]=0.38，95%置信区间[CI]：0.16 - 0.90）和文盲（AOR = 0.24，95%CI：0.06 - 0.85）感染HCV的风险显著较低。然而，输血史会显著增加感染HIV的风险（AOR = 19.52，95%CI：1.80 - 150.6）。我们的研究证实了研究区域内孕妇中HCV和HIV感染对公共卫生的重要性。该研究表明，对于农村居民和有文化的人群，需要关注HCV预防，以及国家血库需要检查用于输血的HIV检测方法。
